Probiotics and carriage of Streptococcus pneumoniae serotypes in Danish children, a double-blind randomized controlled trial

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Standard

Probiotics and carriage of Streptococcus pneumoniae serotypes in Danish children, a double-blind randomized controlled trial. / Fjeldhøj, Sine; Laursen, Rikke Pilmann; Larnkjær, Anni; Mølgaard, Christian; Fuursted, Kurt; Krogfelt, Karen Angeliki; Slotved, Hans-Christian.

I: Scientific Reports, Bind 8, 15258, 2018.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Fjeldhøj, S, Laursen, RP, Larnkjær, A, Mølgaard, C, Fuursted, K, Krogfelt, KA & Slotved, H-C 2018, 'Probiotics and carriage of Streptococcus pneumoniae serotypes in Danish children, a double-blind randomized controlled trial', Scientific Reports, bind 8, 15258. https://doi.org/10.1038/s41598-018-33583-9

APA

Fjeldhøj, S., Laursen, R. P., Larnkjær, A., Mølgaard, C., Fuursted, K., Krogfelt, K. A., & Slotved, H-C. (2018). Probiotics and carriage of Streptococcus pneumoniae serotypes in Danish children, a double-blind randomized controlled trial. Scientific Reports, 8, [15258]. https://doi.org/10.1038/s41598-018-33583-9

Vancouver

Fjeldhøj S, Laursen RP, Larnkjær A, Mølgaard C, Fuursted K, Krogfelt KA o.a. Probiotics and carriage of Streptococcus pneumoniae serotypes in Danish children, a double-blind randomized controlled trial. Scientific Reports. 2018;8. 15258. https://doi.org/10.1038/s41598-018-33583-9

Author

Fjeldhøj, Sine ; Laursen, Rikke Pilmann ; Larnkjær, Anni ; Mølgaard, Christian ; Fuursted, Kurt ; Krogfelt, Karen Angeliki ; Slotved, Hans-Christian. / Probiotics and carriage of Streptococcus pneumoniae serotypes in Danish children, a double-blind randomized controlled trial. I: Scientific Reports. 2018 ; Bind 8.

Bibtex

@article{5061fde8dba449b49d19632a5d501d43,
title = "Probiotics and carriage of Streptococcus pneumoniae serotypes in Danish children, a double-blind randomized controlled trial",
abstract = "This study examined the carriage of Streptococcus pneumoniae in healthy Danish children aged 8-19 months and assessed the effect of the probiotics Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp lactis on the pneumococcal carriage during daycare enrolment. Potential risk factors of pneumococcal carriage were analysed and the carriage study was compared with registered invasive pneumococcal disease (IPD) data. This study is a part of the ProbiComp study, which was a double-blind, randomized controlled trial, including 290 children allocated to probiotics or placebo for 6 months and recruited during two autumn seasons (2014/2015). Pneumococci were identified by optochin sensitivity, bile solubility, α-hemolysis and/or capsular reaction. Serotyping was performed by latex agglutination kit and Quellung reaction. The carriage rate of S. pneumoniae was 26.0{\%} at baseline and 67.4{\%} at the end of intervention. No significant difference was observed between the placebo group and the probiotics group (p = 0.508). Children aged 8-19 months were carriers of non-pneumococcal vaccine serotypes causing IPD in children aged 0-4 years. However, serotypes causing most IPD cases in Danish elderly were either not found or found with low prevalence suggesting that children are not the main reservoir of those serotypes and other age groups need to be considered as carriers.",
author = "Sine Fjeldh{\o}j and Laursen, {Rikke Pilmann} and Anni Larnkj{\ae}r and Christian M{\o}lgaard and Kurt Fuursted and Krogfelt, {Karen Angeliki} and Hans-Christian Slotved",
note = "CURIS 2018 NEXS 359",
year = "2018",
doi = "10.1038/s41598-018-33583-9",
language = "English",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Probiotics and carriage of Streptococcus pneumoniae serotypes in Danish children, a double-blind randomized controlled trial

AU - Fjeldhøj, Sine

AU - Laursen, Rikke Pilmann

AU - Larnkjær, Anni

AU - Mølgaard, Christian

AU - Fuursted, Kurt

AU - Krogfelt, Karen Angeliki

AU - Slotved, Hans-Christian

N1 - CURIS 2018 NEXS 359

PY - 2018

Y1 - 2018

N2 - This study examined the carriage of Streptococcus pneumoniae in healthy Danish children aged 8-19 months and assessed the effect of the probiotics Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp lactis on the pneumococcal carriage during daycare enrolment. Potential risk factors of pneumococcal carriage were analysed and the carriage study was compared with registered invasive pneumococcal disease (IPD) data. This study is a part of the ProbiComp study, which was a double-blind, randomized controlled trial, including 290 children allocated to probiotics or placebo for 6 months and recruited during two autumn seasons (2014/2015). Pneumococci were identified by optochin sensitivity, bile solubility, α-hemolysis and/or capsular reaction. Serotyping was performed by latex agglutination kit and Quellung reaction. The carriage rate of S. pneumoniae was 26.0% at baseline and 67.4% at the end of intervention. No significant difference was observed between the placebo group and the probiotics group (p = 0.508). Children aged 8-19 months were carriers of non-pneumococcal vaccine serotypes causing IPD in children aged 0-4 years. However, serotypes causing most IPD cases in Danish elderly were either not found or found with low prevalence suggesting that children are not the main reservoir of those serotypes and other age groups need to be considered as carriers.

AB - This study examined the carriage of Streptococcus pneumoniae in healthy Danish children aged 8-19 months and assessed the effect of the probiotics Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp lactis on the pneumococcal carriage during daycare enrolment. Potential risk factors of pneumococcal carriage were analysed and the carriage study was compared with registered invasive pneumococcal disease (IPD) data. This study is a part of the ProbiComp study, which was a double-blind, randomized controlled trial, including 290 children allocated to probiotics or placebo for 6 months and recruited during two autumn seasons (2014/2015). Pneumococci were identified by optochin sensitivity, bile solubility, α-hemolysis and/or capsular reaction. Serotyping was performed by latex agglutination kit and Quellung reaction. The carriage rate of S. pneumoniae was 26.0% at baseline and 67.4% at the end of intervention. No significant difference was observed between the placebo group and the probiotics group (p = 0.508). Children aged 8-19 months were carriers of non-pneumococcal vaccine serotypes causing IPD in children aged 0-4 years. However, serotypes causing most IPD cases in Danish elderly were either not found or found with low prevalence suggesting that children are not the main reservoir of those serotypes and other age groups need to be considered as carriers.

U2 - 10.1038/s41598-018-33583-9

DO - 10.1038/s41598-018-33583-9

M3 - Journal article

C2 - 30323328

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 15258

ER -

ID: 204084277