TY - JOUR

T1 - Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention

AU - Hjorth, Mads Fiil

AU - Roager, Henrik Munch

AU - Larsen, Thomas Meinert

AU - Poulsen, Sanne Kellebjerg

AU - Licht, Tine Rask

AU - Bahl, Martin I

AU - Zohar, Yishai

AU - Astrup, Arne

N1 - CURIS 2018 NEXS 113 Corrigendum: 06 February 2018 (jf. link via DOI)

PY - 2018

Y1 - 2018

N2 - Based on the abundance of specific bacterial genera, the human gut microbiota can be divided into two relatively stable groups that might play a role in personalized nutrition. We studied these simplified enterotypes as prognostic markers for successful body fat loss on two different diets. A total of 62 participants with increased waist circumference were randomly assigned to receive an ad libitum New Nordic Diet (NND) high in fiber/wholegrain or an Average Danish Diet (ADD) for 26 weeks. Participants were grouped into two discrete enterotypes by their relative abundance of Prevotella spp. divided by Bacteroides spp. (P/B ratio) obtained by quantitative PCR analysis. Modifications of dietary effects of pre-treatment P/B group were examined by linear mixed models. Among individuals with high P/B the NND resulted in a 3.15 kg (95%CI 1.55;4.76, P<0.001) larger body fat loss compared to ADD whereas no differences was observed among individuals with low P/B (0.88 kg [95% CI -0.61;2.37, P=0.25]). Consequently, a 2.27 kg (95%CI 0.09;4.45, P=0.041) difference in responsiveness to the diets were found between the two groups. In summary, subjects with high P/B-ratio appeared more susceptible to lose body fat on diets high in fiber and wholegrain than subjects with a low P/B-ratio.International Journal of Obesity accepted article preview online, 08 September 2017. doi:10.1038/ijo.2017.220.

AB - Based on the abundance of specific bacterial genera, the human gut microbiota can be divided into two relatively stable groups that might play a role in personalized nutrition. We studied these simplified enterotypes as prognostic markers for successful body fat loss on two different diets. A total of 62 participants with increased waist circumference were randomly assigned to receive an ad libitum New Nordic Diet (NND) high in fiber/wholegrain or an Average Danish Diet (ADD) for 26 weeks. Participants were grouped into two discrete enterotypes by their relative abundance of Prevotella spp. divided by Bacteroides spp. (P/B ratio) obtained by quantitative PCR analysis. Modifications of dietary effects of pre-treatment P/B group were examined by linear mixed models. Among individuals with high P/B the NND resulted in a 3.15 kg (95%CI 1.55;4.76, P<0.001) larger body fat loss compared to ADD whereas no differences was observed among individuals with low P/B (0.88 kg [95% CI -0.61;2.37, P=0.25]). Consequently, a 2.27 kg (95%CI 0.09;4.45, P=0.041) difference in responsiveness to the diets were found between the two groups. In summary, subjects with high P/B-ratio appeared more susceptible to lose body fat on diets high in fiber and wholegrain than subjects with a low P/B-ratio.International Journal of Obesity accepted article preview online, 08 September 2017. doi:10.1038/ijo.2017.220.

KW - Journal Article

UR - https://dx.doi.org/10.1038/ijo.2018.1

U2 - 10.1038/ijo.2017.220

DO - 10.1038/ijo.2017.220

M3 - Journal article

C2 - 28883543

VL - 42

SP - 580

EP - 503

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

ER -