Predictors of successful weight loss with relative maintenance of fat-free mass in individuals with overweight and obesity on an 8-week low-energy diet
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Predictors of successful weight loss with relative maintenance of fat-free mass in individuals with overweight and obesity on an 8-week low-energy diet. / Hansen, Thea Toft; Hjorth, Mads Fiil; Sandby, Karoline; Andersen, Sarah Vold; Astrup, Arne; Ritz, Christian; Bulló, Mònica; Camacho-Barcía, Maria Lucia; García-Gavilán, Jesús Francisco; Salas-Salvadó, Jordi; Harrold, Joanne A; Halford, Jason C G; Sjödin, Anders Mikael.
I: British Journal of Nutrition, Bind 122, Nr. 4, 2019, s. 468-479.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Predictors of successful weight loss with relative maintenance of fat-free mass in individuals with overweight and obesity on an 8-week low-energy diet
AU - Hansen, Thea Toft
AU - Hjorth, Mads Fiil
AU - Sandby, Karoline
AU - Andersen, Sarah Vold
AU - Astrup, Arne
AU - Ritz, Christian
AU - Bulló, Mònica
AU - Camacho-Barcía, Maria Lucia
AU - García-Gavilán, Jesús Francisco
AU - Salas-Salvadó, Jordi
AU - Harrold, Joanne A
AU - Halford, Jason C G
AU - Sjödin, Anders Mikael
N1 - CURIS 2019 NEXS 224 (Embargo)
PY - 2019
Y1 - 2019
N2 - A low-energy diet (LED) is an effective approach to induce a rapid weight loss in individuals with overweight. However, reported disproportionally large losses of fat-free mass (FFM) after an LED trigger the question of adequate protein content. Additionally, not all individuals have the same degree of weight loss success. After an 8-week LED providing 5020 kJ/d for men and 4184 kJ/d for women (84/70 g protein/d) among overweight and obese adults, we aimed to investigate the relationship between protein intake relative to initial FFM and proportion of weight lost as FFM as well as the individual characteristics associated with weight loss success. We assessed all outcomes baseline and after the LED. A total of 286 participants (sixty-four men and 222 women) initiated the LED of which 82 % completed and 70 % achieved a substantial weight loss (defined as ≥8 %). Protein intake in the range 1·0-1·6 g protein/d per kg FFM at baseline for men and 1·1-2·2 g protein/d per kg FFM at baseline for women was not associated with loss of FFM (P = 0·632). Higher Three-Factor Eating Questionnaire (TFEQ) hunger at baseline and reductions in TFEQ disinhibition and hunger during the LED were associated with larger weight loss (all P ≤ 0·020); whereas lower sleep quality at baseline predicted less successful weight loss using intention to treat analysis (P = 0·021), possibly driven by those dropping out (n 81, P = 0·067 v. completers: n 198, P = 0·659). Thus, the protein intakes relative to initial FFM were sufficient for maintenance of FFM and specific eating behaviour characteristics were associated with weight loss success.
AB - A low-energy diet (LED) is an effective approach to induce a rapid weight loss in individuals with overweight. However, reported disproportionally large losses of fat-free mass (FFM) after an LED trigger the question of adequate protein content. Additionally, not all individuals have the same degree of weight loss success. After an 8-week LED providing 5020 kJ/d for men and 4184 kJ/d for women (84/70 g protein/d) among overweight and obese adults, we aimed to investigate the relationship between protein intake relative to initial FFM and proportion of weight lost as FFM as well as the individual characteristics associated with weight loss success. We assessed all outcomes baseline and after the LED. A total of 286 participants (sixty-four men and 222 women) initiated the LED of which 82 % completed and 70 % achieved a substantial weight loss (defined as ≥8 %). Protein intake in the range 1·0-1·6 g protein/d per kg FFM at baseline for men and 1·1-2·2 g protein/d per kg FFM at baseline for women was not associated with loss of FFM (P = 0·632). Higher Three-Factor Eating Questionnaire (TFEQ) hunger at baseline and reductions in TFEQ disinhibition and hunger during the LED were associated with larger weight loss (all P ≤ 0·020); whereas lower sleep quality at baseline predicted less successful weight loss using intention to treat analysis (P = 0·021), possibly driven by those dropping out (n 81, P = 0·067 v. completers: n 198, P = 0·659). Thus, the protein intakes relative to initial FFM were sufficient for maintenance of FFM and specific eating behaviour characteristics were associated with weight loss success.
KW - Faculty of Science
KW - Low-energy diets
KW - Appetite
KW - Hunger
KW - Behaviour
KW - Protein
U2 - 10.1017/S0007114519001296
DO - 10.1017/S0007114519001296
M3 - Journal article
C2 - 31242952
VL - 122
SP - 468
EP - 479
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 4
ER -
ID: 223572052