Prediction of critical weight loss during radiation treatment in head and neck cancer patients is dependent on BMI

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Standard

Prediction of critical weight loss during radiation treatment in head and neck cancer patients is dependent on BMI. / Lønbro, Simon; Bjerg Petersen, Gry; Andersen, Jens Rikardt; Johansen, Jørgen.

I: Supportive Care in Cancer, Bind 24, Nr. 5, 2016, s. 2101-2109.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lønbro, S, Bjerg Petersen, G, Andersen, JR & Johansen, J 2016, 'Prediction of critical weight loss during radiation treatment in head and neck cancer patients is dependent on BMI', Supportive Care in Cancer, bind 24, nr. 5, s. 2101-2109. https://doi.org/10.1007/s00520-015-2999-8

APA

Lønbro, S., Bjerg Petersen, G., Andersen, J. R., & Johansen, J. (2016). Prediction of critical weight loss during radiation treatment in head and neck cancer patients is dependent on BMI. Supportive Care in Cancer, 24(5), 2101-2109. https://doi.org/10.1007/s00520-015-2999-8

Vancouver

Lønbro S, Bjerg Petersen G, Andersen JR, Johansen J. Prediction of critical weight loss during radiation treatment in head and neck cancer patients is dependent on BMI. Supportive Care in Cancer. 2016;24(5):2101-2109. https://doi.org/10.1007/s00520-015-2999-8

Author

Lønbro, Simon ; Bjerg Petersen, Gry ; Andersen, Jens Rikardt ; Johansen, Jørgen. / Prediction of critical weight loss during radiation treatment in head and neck cancer patients is dependent on BMI. I: Supportive Care in Cancer. 2016 ; Bind 24, Nr. 5. s. 2101-2109.

Bibtex

@article{48b10aecabbc4368be350abbb39386a7,
title = "Prediction of critical weight loss during radiation treatment in head and neck cancer patients is dependent on BMI",
abstract = "PURPOSE: The aims of the present study were to explore pre-treatment predictors of weight loss during radiation treatment only in head and neck cancer (HNSCC) patients and investigate the weight loss in patients with or without a feeding tube.METHODS: Retrospectively, weight change during curative radiotherapy was investigated in 476 consecutive HNSCC patients. Independent predictors were identified using multivariate regression analysis with weight loss below or above 5 % as the primary dependent variable.RESULTS: Baseline BMI, tumor site, and stage predicted weight loss above 5 %. The odds of weight loss above 5 % in patients with BMI >25 were 3.00 ± 0.64 times higher compared with patients with BMI <25 (p < 0.0001). Patients with pharyngeal, oral cavity, or supraglottic tumors had 3.12 ± 0.80 times higher odds of weight loss above 5 % compared with glottic cancer patients (p < 0.0001), and the odds were 1.68 ± 0.40 times higher in stage III-IV patients compared with stage I-II patients (p = 0.03). Seperate analyses revealed that tumor site and stage only predicted weight loss in patients with BMI >25 but not in patients with BMI <25. Patients receiving a feeding tube weighed less than patients without (73.8 vs 78.3 kg) and feeding tube reduced, but did not prevent, weight loss which averaged 6.7 ± 4.7 kg (7.4 ± 4.7 %) compared with 4.7 ± 5.9 kg (5.5 ± 6.0 %) in patients without a feeding tube (P < 0.0001).CONCLUSION: Pre-treatment BMI, tumor site and stage predicted weight loss above 5 % in HNSCC patients during radiotherapy. BMI should be considered when analyzing weight loss in HNSCC patients receiving curative radiotherapy.",
author = "Simon L{\o}nbro and {Bjerg Petersen}, Gry and Andersen, {Jens Rikardt} and J{\o}rgen Johansen",
note = "CURIS 2016 NEXS 089",
year = "2016",
doi = "10.1007/s00520-015-2999-8",
language = "English",
volume = "24",
pages = "2101--2109",
journal = "Supportive Care in Cancer",
issn = "0941-4355",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Prediction of critical weight loss during radiation treatment in head and neck cancer patients is dependent on BMI

AU - Lønbro, Simon

AU - Bjerg Petersen, Gry

AU - Andersen, Jens Rikardt

AU - Johansen, Jørgen

N1 - CURIS 2016 NEXS 089

PY - 2016

Y1 - 2016

N2 - PURPOSE: The aims of the present study were to explore pre-treatment predictors of weight loss during radiation treatment only in head and neck cancer (HNSCC) patients and investigate the weight loss in patients with or without a feeding tube.METHODS: Retrospectively, weight change during curative radiotherapy was investigated in 476 consecutive HNSCC patients. Independent predictors were identified using multivariate regression analysis with weight loss below or above 5 % as the primary dependent variable.RESULTS: Baseline BMI, tumor site, and stage predicted weight loss above 5 %. The odds of weight loss above 5 % in patients with BMI >25 were 3.00 ± 0.64 times higher compared with patients with BMI <25 (p < 0.0001). Patients with pharyngeal, oral cavity, or supraglottic tumors had 3.12 ± 0.80 times higher odds of weight loss above 5 % compared with glottic cancer patients (p < 0.0001), and the odds were 1.68 ± 0.40 times higher in stage III-IV patients compared with stage I-II patients (p = 0.03). Seperate analyses revealed that tumor site and stage only predicted weight loss in patients with BMI >25 but not in patients with BMI <25. Patients receiving a feeding tube weighed less than patients without (73.8 vs 78.3 kg) and feeding tube reduced, but did not prevent, weight loss which averaged 6.7 ± 4.7 kg (7.4 ± 4.7 %) compared with 4.7 ± 5.9 kg (5.5 ± 6.0 %) in patients without a feeding tube (P < 0.0001).CONCLUSION: Pre-treatment BMI, tumor site and stage predicted weight loss above 5 % in HNSCC patients during radiotherapy. BMI should be considered when analyzing weight loss in HNSCC patients receiving curative radiotherapy.

AB - PURPOSE: The aims of the present study were to explore pre-treatment predictors of weight loss during radiation treatment only in head and neck cancer (HNSCC) patients and investigate the weight loss in patients with or without a feeding tube.METHODS: Retrospectively, weight change during curative radiotherapy was investigated in 476 consecutive HNSCC patients. Independent predictors were identified using multivariate regression analysis with weight loss below or above 5 % as the primary dependent variable.RESULTS: Baseline BMI, tumor site, and stage predicted weight loss above 5 %. The odds of weight loss above 5 % in patients with BMI >25 were 3.00 ± 0.64 times higher compared with patients with BMI <25 (p < 0.0001). Patients with pharyngeal, oral cavity, or supraglottic tumors had 3.12 ± 0.80 times higher odds of weight loss above 5 % compared with glottic cancer patients (p < 0.0001), and the odds were 1.68 ± 0.40 times higher in stage III-IV patients compared with stage I-II patients (p = 0.03). Seperate analyses revealed that tumor site and stage only predicted weight loss in patients with BMI >25 but not in patients with BMI <25. Patients receiving a feeding tube weighed less than patients without (73.8 vs 78.3 kg) and feeding tube reduced, but did not prevent, weight loss which averaged 6.7 ± 4.7 kg (7.4 ± 4.7 %) compared with 4.7 ± 5.9 kg (5.5 ± 6.0 %) in patients without a feeding tube (P < 0.0001).CONCLUSION: Pre-treatment BMI, tumor site and stage predicted weight loss above 5 % in HNSCC patients during radiotherapy. BMI should be considered when analyzing weight loss in HNSCC patients receiving curative radiotherapy.

U2 - 10.1007/s00520-015-2999-8

DO - 10.1007/s00520-015-2999-8

M3 - Journal article

C2 - 26553031

VL - 24

SP - 2101

EP - 2109

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

SN - 0941-4355

IS - 5

ER -

ID: 148053511