Pancreatic insufficiency - Duodenal and jejunal ph, bile acid activity, and micellar lipid solubilization

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Standard

Pancreatic insufficiency - Duodenal and jejunal ph, bile acid activity, and micellar lipid solubilization. / Andersen, Jens Rikardt; Bendtsen, Flemming; Ovesen, Lars; Pedersen, Niels T; Rune, Simon J.; Tage-Jensen, Ulrik.

I: International Journal of Pancreatology, Bind 6, Nr. 4, 1990, s. 263-270.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Andersen, JR, Bendtsen, F, Ovesen, L, Pedersen, NT, Rune, SJ & Tage-Jensen, U 1990, 'Pancreatic insufficiency - Duodenal and jejunal ph, bile acid activity, and micellar lipid solubilization', International Journal of Pancreatology, bind 6, nr. 4, s. 263-270. https://doi.org/10.1007/BF02924405

APA

Andersen, J. R., Bendtsen, F., Ovesen, L., Pedersen, N. T., Rune, S. J., & Tage-Jensen, U. (1990). Pancreatic insufficiency - Duodenal and jejunal ph, bile acid activity, and micellar lipid solubilization. International Journal of Pancreatology, 6(4), 263-270. https://doi.org/10.1007/BF02924405

Vancouver

Andersen JR, Bendtsen F, Ovesen L, Pedersen NT, Rune SJ, Tage-Jensen U. Pancreatic insufficiency - Duodenal and jejunal ph, bile acid activity, and micellar lipid solubilization. International Journal of Pancreatology. 1990;6(4):263-270. https://doi.org/10.1007/BF02924405

Author

Andersen, Jens Rikardt ; Bendtsen, Flemming ; Ovesen, Lars ; Pedersen, Niels T ; Rune, Simon J. ; Tage-Jensen, Ulrik. / Pancreatic insufficiency - Duodenal and jejunal ph, bile acid activity, and micellar lipid solubilization. I: International Journal of Pancreatology. 1990 ; Bind 6, Nr. 4. s. 263-270.

Bibtex

@article{4690e0f2008941fd9553e5319dc02f7b,
title = "Pancreatic insufficiency - Duodenal and jejunal ph, bile acid activity, and micellar lipid solubilization",
abstract = "To investigate the course of postprandial lipid solubilization in nine patients with chronic, alcoholic pancreatitis, luminal contents were aspirated from the proximal part of the jejunum for 180 min after a meal containing 1.5% fat. Six of the patients had pancreatic insufficiency, whereas three patients were without insufficiency. pH was measured continuously at two sites: at the level of the papilla of Vater and the aspiration site. The fraction of bile acids in the micellar phase of the jejunal aspirates correlated positively to both pH in the aspirates (p < 0.05) and the fraction of fat solubilized (p < 0.02). pH was below 4.0 for a longer period of time in the patients with insufficiency, compared to the patients without. However, pH fluctuated rapidly, and there was no correlation between the continuously measured values at the aspiration site and values in the aspirates. Lipid solubilization was not correlated to the lipase activity in the aspirates. We conclude that acidic bile acid precipitation most likely plays a dominant role in the pathophysiology of pancreatic steatorrhea although the methods available are too crude to disclose the precise course of events.",
keywords = "Bile acid physiology, Colloids, Fatty acids, Pancreatic insufficiency, Pancreatitis, pH",
author = "Andersen, {Jens Rikardt} and Flemming Bendtsen and Lars Ovesen and Pedersen, {Niels T} and Rune, {Simon J.} and Ulrik Tage-Jensen",
note = "(Ekstern)",
year = "1990",
doi = "10.1007/BF02924405",
language = "English",
volume = "6",
pages = "263--270",
journal = "International Journal of Pancreatology",
issn = "0169-4197",
publisher = "Humana Press",
number = "4",

}

RIS

TY - JOUR

T1 - Pancreatic insufficiency - Duodenal and jejunal ph, bile acid activity, and micellar lipid solubilization

AU - Andersen, Jens Rikardt

AU - Bendtsen, Flemming

AU - Ovesen, Lars

AU - Pedersen, Niels T

AU - Rune, Simon J.

AU - Tage-Jensen, Ulrik

N1 - (Ekstern)

PY - 1990

Y1 - 1990

N2 - To investigate the course of postprandial lipid solubilization in nine patients with chronic, alcoholic pancreatitis, luminal contents were aspirated from the proximal part of the jejunum for 180 min after a meal containing 1.5% fat. Six of the patients had pancreatic insufficiency, whereas three patients were without insufficiency. pH was measured continuously at two sites: at the level of the papilla of Vater and the aspiration site. The fraction of bile acids in the micellar phase of the jejunal aspirates correlated positively to both pH in the aspirates (p < 0.05) and the fraction of fat solubilized (p < 0.02). pH was below 4.0 for a longer period of time in the patients with insufficiency, compared to the patients without. However, pH fluctuated rapidly, and there was no correlation between the continuously measured values at the aspiration site and values in the aspirates. Lipid solubilization was not correlated to the lipase activity in the aspirates. We conclude that acidic bile acid precipitation most likely plays a dominant role in the pathophysiology of pancreatic steatorrhea although the methods available are too crude to disclose the precise course of events.

AB - To investigate the course of postprandial lipid solubilization in nine patients with chronic, alcoholic pancreatitis, luminal contents were aspirated from the proximal part of the jejunum for 180 min after a meal containing 1.5% fat. Six of the patients had pancreatic insufficiency, whereas three patients were without insufficiency. pH was measured continuously at two sites: at the level of the papilla of Vater and the aspiration site. The fraction of bile acids in the micellar phase of the jejunal aspirates correlated positively to both pH in the aspirates (p < 0.05) and the fraction of fat solubilized (p < 0.02). pH was below 4.0 for a longer period of time in the patients with insufficiency, compared to the patients without. However, pH fluctuated rapidly, and there was no correlation between the continuously measured values at the aspiration site and values in the aspirates. Lipid solubilization was not correlated to the lipase activity in the aspirates. We conclude that acidic bile acid precipitation most likely plays a dominant role in the pathophysiology of pancreatic steatorrhea although the methods available are too crude to disclose the precise course of events.

KW - Bile acid physiology

KW - Colloids

KW - Fatty acids

KW - Pancreatic insufficiency

KW - Pancreatitis

KW - pH

UR - http://www.scopus.com/inward/record.url?scp=0025350434&partnerID=8YFLogxK

U2 - 10.1007/BF02924405

DO - 10.1007/BF02924405

M3 - Journal article

C2 - 2212745

AN - SCOPUS:0025350434

VL - 6

SP - 263

EP - 270

JO - International Journal of Pancreatology

JF - International Journal of Pancreatology

SN - 0169-4197

IS - 4

ER -

ID: 251990809