Na+,K+-ATPase concentration in rodent and human heart and skeletal muscle: apparent relation to muscle performance

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Standard

Na+,K+-ATPase concentration in rodent and human heart and skeletal muscle : apparent relation to muscle performance. / Kjeldsen, K; Bjerregaard, P; Richter, Erik A.; Thomsen, P E; Nørgaard, A.

I: Cardiovascular Research, Bind 22, Nr. 2, 1988, s. 95-100.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Kjeldsen, K, Bjerregaard, P, Richter, EA, Thomsen, PE & Nørgaard, A 1988, 'Na+,K+-ATPase concentration in rodent and human heart and skeletal muscle: apparent relation to muscle performance', Cardiovascular Research, bind 22, nr. 2, s. 95-100.

APA

Kjeldsen, K., Bjerregaard, P., Richter, E. A., Thomsen, P. E., & Nørgaard, A. (1988). Na+,K+-ATPase concentration in rodent and human heart and skeletal muscle: apparent relation to muscle performance. Cardiovascular Research, 22(2), 95-100.

Vancouver

Kjeldsen K, Bjerregaard P, Richter EA, Thomsen PE, Nørgaard A. Na+,K+-ATPase concentration in rodent and human heart and skeletal muscle: apparent relation to muscle performance. Cardiovascular Research. 1988;22(2):95-100.

Author

Kjeldsen, K ; Bjerregaard, P ; Richter, Erik A. ; Thomsen, P E ; Nørgaard, A. / Na+,K+-ATPase concentration in rodent and human heart and skeletal muscle : apparent relation to muscle performance. I: Cardiovascular Research. 1988 ; Bind 22, Nr. 2. s. 95-100.

Bibtex

@article{761dcdb57db3403991feed7c3baa2cb7,
title = "Na+,K+-ATPase concentration in rodent and human heart and skeletal muscle: apparent relation to muscle performance",
abstract = "To investigate whether the sodium-potassium pump or Na+,K+-ATPase concentration in muscles is related to the capacity for muscle performance, the 3H-ouabain binding site concentration or 3-O-methylflourescein phosphatase activity was determined in samples of heart ventricular muscles from trained rats, cardiomyopathic hamsters, and human subjects. These methods have earlier been shown to quantify the Na+,K+-ATPase concentration in muscle tissue with high accuracy. When rats were swim trained for six weeks the heart ventricular muscle Na+,K+-ATPase concentration was increased by 20{\%} (p less than 0.02) and the heart to body weight ratio by 14{\%} (p less than 0.005). The increase in Na+,K+-ATPase concentration was only slowly reversible. After three weeks of deconditioning an increase of 12{\%} (p less than 0.05) was still observed. In comparison skeletal muscle Na+,K+-ATPase concentration was increased by up to 46{\%} (p less than 0.001) and decreased by up to 30{\%} (p less than 0.005) after training and immobilisation respectively. Cardiomyopathic hamsters showed a reduction of 33{\%} (p less than 0.005) in the heart ventricular Na+,K+-ATPase concentration compared with normal hamsters. This decrease was associated with a heart to body weight increase of 19{\%} (p less than 0.01) and congestive heart failure. In six patients with a mean ventricular ejection fraction of 68{\%} the mean Na+,K+-ATPase concentration in endomyocardial biopsy specimens obtained by left heart catheterisation was 505(41) compared with 322(32) pmol.g-1 wet wt (p less than 0.001) in nine patients with a mean ejection fraction of 29{\%}. Taken together the present data indicate a relation between the Na+,K+-ATPase concentration and the capacity for muscle performance.",
keywords = "Animals, Cardiomyopathies, Cricetinae, Female, Heart Ventricles, Humans, Muscles, Myocardium, Physical Conditioning, Animal, Rats, Sodium-Potassium-Exchanging ATPase",
author = "K Kjeldsen and P Bjerregaard and Richter, {Erik A.} and Thomsen, {P E} and A N{\o}rgaard",
year = "1988",
language = "English",
volume = "22",
pages = "95--100",
journal = "Cardiovascular Research",
issn = "0008-6363",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Na+,K+-ATPase concentration in rodent and human heart and skeletal muscle

T2 - apparent relation to muscle performance

AU - Kjeldsen, K

AU - Bjerregaard, P

AU - Richter, Erik A.

AU - Thomsen, P E

AU - Nørgaard, A

PY - 1988

Y1 - 1988

N2 - To investigate whether the sodium-potassium pump or Na+,K+-ATPase concentration in muscles is related to the capacity for muscle performance, the 3H-ouabain binding site concentration or 3-O-methylflourescein phosphatase activity was determined in samples of heart ventricular muscles from trained rats, cardiomyopathic hamsters, and human subjects. These methods have earlier been shown to quantify the Na+,K+-ATPase concentration in muscle tissue with high accuracy. When rats were swim trained for six weeks the heart ventricular muscle Na+,K+-ATPase concentration was increased by 20% (p less than 0.02) and the heart to body weight ratio by 14% (p less than 0.005). The increase in Na+,K+-ATPase concentration was only slowly reversible. After three weeks of deconditioning an increase of 12% (p less than 0.05) was still observed. In comparison skeletal muscle Na+,K+-ATPase concentration was increased by up to 46% (p less than 0.001) and decreased by up to 30% (p less than 0.005) after training and immobilisation respectively. Cardiomyopathic hamsters showed a reduction of 33% (p less than 0.005) in the heart ventricular Na+,K+-ATPase concentration compared with normal hamsters. This decrease was associated with a heart to body weight increase of 19% (p less than 0.01) and congestive heart failure. In six patients with a mean ventricular ejection fraction of 68% the mean Na+,K+-ATPase concentration in endomyocardial biopsy specimens obtained by left heart catheterisation was 505(41) compared with 322(32) pmol.g-1 wet wt (p less than 0.001) in nine patients with a mean ejection fraction of 29%. Taken together the present data indicate a relation between the Na+,K+-ATPase concentration and the capacity for muscle performance.

AB - To investigate whether the sodium-potassium pump or Na+,K+-ATPase concentration in muscles is related to the capacity for muscle performance, the 3H-ouabain binding site concentration or 3-O-methylflourescein phosphatase activity was determined in samples of heart ventricular muscles from trained rats, cardiomyopathic hamsters, and human subjects. These methods have earlier been shown to quantify the Na+,K+-ATPase concentration in muscle tissue with high accuracy. When rats were swim trained for six weeks the heart ventricular muscle Na+,K+-ATPase concentration was increased by 20% (p less than 0.02) and the heart to body weight ratio by 14% (p less than 0.005). The increase in Na+,K+-ATPase concentration was only slowly reversible. After three weeks of deconditioning an increase of 12% (p less than 0.05) was still observed. In comparison skeletal muscle Na+,K+-ATPase concentration was increased by up to 46% (p less than 0.001) and decreased by up to 30% (p less than 0.005) after training and immobilisation respectively. Cardiomyopathic hamsters showed a reduction of 33% (p less than 0.005) in the heart ventricular Na+,K+-ATPase concentration compared with normal hamsters. This decrease was associated with a heart to body weight increase of 19% (p less than 0.01) and congestive heart failure. In six patients with a mean ventricular ejection fraction of 68% the mean Na+,K+-ATPase concentration in endomyocardial biopsy specimens obtained by left heart catheterisation was 505(41) compared with 322(32) pmol.g-1 wet wt (p less than 0.001) in nine patients with a mean ejection fraction of 29%. Taken together the present data indicate a relation between the Na+,K+-ATPase concentration and the capacity for muscle performance.

KW - Animals

KW - Cardiomyopathies

KW - Cricetinae

KW - Female

KW - Heart Ventricles

KW - Humans

KW - Muscles

KW - Myocardium

KW - Physical Conditioning, Animal

KW - Rats

KW - Sodium-Potassium-Exchanging ATPase

M3 - Journal article

C2 - 2844406

VL - 22

SP - 95

EP - 100

JO - Cardiovascular Research

JF - Cardiovascular Research

SN - 0008-6363

IS - 2

ER -

ID: 154757738