N-Acetyl cysteine does not improve repeated intense endurance cycling performance of well-trained cyclists

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N-Acetyl cysteine does not improve repeated intense endurance cycling performance of well-trained cyclists. / Christensen, Peter Møller; Bangsbo, Jens.

I: European Journal of Applied Physiology, Bind 119, Nr. 6, 2019, s. 1419-1429.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Christensen, PM & Bangsbo, J 2019, 'N-Acetyl cysteine does not improve repeated intense endurance cycling performance of well-trained cyclists', European Journal of Applied Physiology, bind 119, nr. 6, s. 1419-1429. https://doi.org/10.1007/s00421-019-04132-7

APA

Christensen, P. M., & Bangsbo, J. (2019). N-Acetyl cysteine does not improve repeated intense endurance cycling performance of well-trained cyclists. European Journal of Applied Physiology, 119(6), 1419-1429. https://doi.org/10.1007/s00421-019-04132-7

Vancouver

Christensen PM, Bangsbo J. N-Acetyl cysteine does not improve repeated intense endurance cycling performance of well-trained cyclists. European Journal of Applied Physiology. 2019;119(6):1419-1429. https://doi.org/10.1007/s00421-019-04132-7

Author

Christensen, Peter Møller ; Bangsbo, Jens. / N-Acetyl cysteine does not improve repeated intense endurance cycling performance of well-trained cyclists. I: European Journal of Applied Physiology. 2019 ; Bind 119, Nr. 6. s. 1419-1429.

Bibtex

@article{6b4b27710fde4fdb9edb06f9266b3d14,
title = "N-Acetyl cysteine does not improve repeated intense endurance cycling performance of well-trained cyclists",
abstract = "Purpose: To evaluate the effect of antioxidant supplementation on intense endurance exercise performance and the physiologic exercise response acutely and in early recovery.Methods: Well-trained cyclists (n = 11, peak VO2: 69 ± 7 ml/min/kg) completed two identical standardized 20-min warm-up periods (WU-1 and WU-2) prior to two performance tests (PT) with a duration of ~ 4 min representing a qualifying (PT-1) and final race (PT-2) on the same day separated by 90 min. Subjects were supplemented orally with placebo (PLA) and N-acetyl cysteine (NAC; 20 mg/kg) before exercise in a double-blinded crossover design.Results: Mean power during PT-1 did not differ (P = 0.39) between PLA (400 ± 44 W) and NAC (401 ± 44 W) as was the case during PT-2 with similar performance (P = 0.74) between PLA (401 ± 43 W) and NAC (400 ± 42 W). Subjective {"}readiness{"} was lowered by prior exhaustive exercise from PT-1 to PT-2 (P = 0.012) in both PLA and NAC. Plasma total antioxidant capacity was not affected by supplementation and prior exhaustive exercise (respective main effects: P = 0.83 and P = 0.19) which also was observed for peak VO2 at ~ 5 L/min (P = 0.84 and P = 0.30). In WU-1 and WU-2, both cycling economy at ~ 20{\%} (P = 0.10 and P = 0.21) and plasma potassium at ~ 5 mmol/L (P = 0.46 and P = 0.26) were unaffected by supplementation and prior exercise.Conclusions: Athletes executing maximal efforts of a ~ 4-min duration twice daily, as seen in track cycling, appear to gain no benefit from oral NAC supplementation on acute and subsequent performance following short-term recovery. Moreover, well-trained cyclists exhibit rapid recovery from a single bout of intense endurance cycling.",
keywords = "Faculty of Science, NAC, Gross efficiency, TAC, Cycling, ROS, VO2-max",
author = "Christensen, {Peter M{\o}ller} and Jens Bangsbo",
note = "CURIS 2019 NEXS 151",
year = "2019",
doi = "10.1007/s00421-019-04132-7",
language = "English",
volume = "119",
pages = "1419--1429",
journal = "European Journal of Applied Physiology",
issn = "1439-6319",
publisher = "Springer",
number = "6",

}

RIS

TY - JOUR

T1 - N-Acetyl cysteine does not improve repeated intense endurance cycling performance of well-trained cyclists

AU - Christensen, Peter Møller

AU - Bangsbo, Jens

N1 - CURIS 2019 NEXS 151

PY - 2019

Y1 - 2019

N2 - Purpose: To evaluate the effect of antioxidant supplementation on intense endurance exercise performance and the physiologic exercise response acutely and in early recovery.Methods: Well-trained cyclists (n = 11, peak VO2: 69 ± 7 ml/min/kg) completed two identical standardized 20-min warm-up periods (WU-1 and WU-2) prior to two performance tests (PT) with a duration of ~ 4 min representing a qualifying (PT-1) and final race (PT-2) on the same day separated by 90 min. Subjects were supplemented orally with placebo (PLA) and N-acetyl cysteine (NAC; 20 mg/kg) before exercise in a double-blinded crossover design.Results: Mean power during PT-1 did not differ (P = 0.39) between PLA (400 ± 44 W) and NAC (401 ± 44 W) as was the case during PT-2 with similar performance (P = 0.74) between PLA (401 ± 43 W) and NAC (400 ± 42 W). Subjective "readiness" was lowered by prior exhaustive exercise from PT-1 to PT-2 (P = 0.012) in both PLA and NAC. Plasma total antioxidant capacity was not affected by supplementation and prior exhaustive exercise (respective main effects: P = 0.83 and P = 0.19) which also was observed for peak VO2 at ~ 5 L/min (P = 0.84 and P = 0.30). In WU-1 and WU-2, both cycling economy at ~ 20% (P = 0.10 and P = 0.21) and plasma potassium at ~ 5 mmol/L (P = 0.46 and P = 0.26) were unaffected by supplementation and prior exercise.Conclusions: Athletes executing maximal efforts of a ~ 4-min duration twice daily, as seen in track cycling, appear to gain no benefit from oral NAC supplementation on acute and subsequent performance following short-term recovery. Moreover, well-trained cyclists exhibit rapid recovery from a single bout of intense endurance cycling.

AB - Purpose: To evaluate the effect of antioxidant supplementation on intense endurance exercise performance and the physiologic exercise response acutely and in early recovery.Methods: Well-trained cyclists (n = 11, peak VO2: 69 ± 7 ml/min/kg) completed two identical standardized 20-min warm-up periods (WU-1 and WU-2) prior to two performance tests (PT) with a duration of ~ 4 min representing a qualifying (PT-1) and final race (PT-2) on the same day separated by 90 min. Subjects were supplemented orally with placebo (PLA) and N-acetyl cysteine (NAC; 20 mg/kg) before exercise in a double-blinded crossover design.Results: Mean power during PT-1 did not differ (P = 0.39) between PLA (400 ± 44 W) and NAC (401 ± 44 W) as was the case during PT-2 with similar performance (P = 0.74) between PLA (401 ± 43 W) and NAC (400 ± 42 W). Subjective "readiness" was lowered by prior exhaustive exercise from PT-1 to PT-2 (P = 0.012) in both PLA and NAC. Plasma total antioxidant capacity was not affected by supplementation and prior exhaustive exercise (respective main effects: P = 0.83 and P = 0.19) which also was observed for peak VO2 at ~ 5 L/min (P = 0.84 and P = 0.30). In WU-1 and WU-2, both cycling economy at ~ 20% (P = 0.10 and P = 0.21) and plasma potassium at ~ 5 mmol/L (P = 0.46 and P = 0.26) were unaffected by supplementation and prior exercise.Conclusions: Athletes executing maximal efforts of a ~ 4-min duration twice daily, as seen in track cycling, appear to gain no benefit from oral NAC supplementation on acute and subsequent performance following short-term recovery. Moreover, well-trained cyclists exhibit rapid recovery from a single bout of intense endurance cycling.

KW - Faculty of Science

KW - NAC

KW - Gross efficiency

KW - TAC

KW - Cycling

KW - ROS

KW - VO2-max

U2 - 10.1007/s00421-019-04132-7

DO - 10.1007/s00421-019-04132-7

M3 - Journal article

C2 - 31030296

VL - 119

SP - 1419

EP - 1429

JO - European Journal of Applied Physiology

JF - European Journal of Applied Physiology

SN - 1439-6319

IS - 6

ER -

ID: 217517153