TY - JOUR

T1 - Mechanisms underlying absent training-induced improvement in insulin action in lean, hyperandrogenic women with polycystic ovary syndrome

AU - Hansen, Solvejg Lis

AU - Bojsen-Møller, Kirstine N

AU - Lundsgaard, Anne-Marie

AU - Hendrich, Frederikke L

AU - Nilas, Lisbeth

AU - Sjøberg, Kim Anker

AU - Hingst, Janne Rasmuss

AU - Serup, Annette Karen

AU - Henríquez-Olguín, Carlos

AU - Carl, Christian Strini

AU - Wernblad, Louise F

AU - Henneberg, Marie

AU - Lustrup, Katja M

AU - Hansen, Christine

AU - Jensen, Thomas Elbenhardt

AU - Madsbad, Sten

AU - Wojtaszewski, Jørgen

AU - Richter, Erik A.

AU - Kiens, Bente

N1 - © 2020 by the American Diabetes Association.

PY - 2020

Y1 - 2020

N2 - Women with polycystic ovary syndrome (PCOS) have been shown to be less insulin sensitive compared with control (CON) women, independent of BMI. Training is associated with molecular adaptations in skeletal muscle, improving glucose uptake and metabolism in both healthy individuals and patients type 2 diabetes. In the current study, lean hyperandrogenic women with PCOS (n = 9) and healthy CON women (n = 9) completed 14 weeks of controlled and supervised exercise training. In CON, the training intervention increased whole body insulin action by 26% and insulin-stimulated leg glucose uptake by 53%, together with increased insulin-stimulated leg blood flow and a more oxidative muscle fiber type distribution. In PCOS, no such changes were found, despite similar training intensity and improvements in VO2max. In skeletal muscle of CON but not PCOS, training increased GLUT4 and HKII mRNA and protein expressions. These data suggest that the impaired increase in whole-body insulin action in women with PCOS with training is caused by an impaired ability to upregulate key glucose-handling proteins for insulin-stimulated glucose uptake in skeletal muscle and insulin-stimulated leg blood flow. Still, other important benefits of exercise training appeared in women with PCOS, including an improvement of the hyperandrogenic state.

AB - Women with polycystic ovary syndrome (PCOS) have been shown to be less insulin sensitive compared with control (CON) women, independent of BMI. Training is associated with molecular adaptations in skeletal muscle, improving glucose uptake and metabolism in both healthy individuals and patients type 2 diabetes. In the current study, lean hyperandrogenic women with PCOS (n = 9) and healthy CON women (n = 9) completed 14 weeks of controlled and supervised exercise training. In CON, the training intervention increased whole body insulin action by 26% and insulin-stimulated leg glucose uptake by 53%, together with increased insulin-stimulated leg blood flow and a more oxidative muscle fiber type distribution. In PCOS, no such changes were found, despite similar training intensity and improvements in VO2max. In skeletal muscle of CON but not PCOS, training increased GLUT4 and HKII mRNA and protein expressions. These data suggest that the impaired increase in whole-body insulin action in women with PCOS with training is caused by an impaired ability to upregulate key glucose-handling proteins for insulin-stimulated glucose uptake in skeletal muscle and insulin-stimulated leg blood flow. Still, other important benefits of exercise training appeared in women with PCOS, including an improvement of the hyperandrogenic state.

U2 - 10.2337/db20-0062

DO - 10.2337/db20-0062

M3 - Journal article

C2 - 32873590

VL - 69

SP - 2267

EP - 2280

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 11

ER -