Low blood flow at onset of moderate intensity exercise does not limit muscle oxygen uptake

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Standard

Low blood flow at onset of moderate intensity exercise does not limit muscle oxygen uptake. / Nyberg, Michael Permin; Mortensen, Stefan Peter; Saltin, Bengt; Hellsten, Ylva; Bangsbo, Jens.

I: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Bind 298, Nr. 3, 2010, s. R843-R848.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Nyberg, MP, Mortensen, SP, Saltin, B, Hellsten, Y & Bangsbo, J 2010, 'Low blood flow at onset of moderate intensity exercise does not limit muscle oxygen uptake', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, bind 298, nr. 3, s. R843-R848. https://doi.org/10.1152/ajpregu.00730.2009

APA

Nyberg, M. P., Mortensen, S. P., Saltin, B., Hellsten, Y., & Bangsbo, J. (2010). Low blood flow at onset of moderate intensity exercise does not limit muscle oxygen uptake. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 298(3), R843-R848. https://doi.org/10.1152/ajpregu.00730.2009

Vancouver

Nyberg MP, Mortensen SP, Saltin B, Hellsten Y, Bangsbo J. Low blood flow at onset of moderate intensity exercise does not limit muscle oxygen uptake. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 2010;298(3):R843-R848. https://doi.org/10.1152/ajpregu.00730.2009

Author

Nyberg, Michael Permin ; Mortensen, Stefan Peter ; Saltin, Bengt ; Hellsten, Ylva ; Bangsbo, Jens. / Low blood flow at onset of moderate intensity exercise does not limit muscle oxygen uptake. I: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 2010 ; Bind 298, Nr. 3. s. R843-R848.

Bibtex

@article{77a2dd00158511df803f000ea68e967b,
title = "Low blood flow at onset of moderate intensity exercise does not limit muscle oxygen uptake",
abstract = "The effect of low blood flow at onset of moderate intensity exercise on the rate of rise in muscle oxygen uptake was examined. Seven male subjects performed a 3.5 minute one-legged knee-extensor exercise bout (24+/-1 (+/-S.D.) W) without (CON) and with (double blockade; DB) arterial infusion of inhibitors of nitric oxide synthase (NOS; L-NMMA) and cyclooxygenase (COX; indomethacin) in order to inhibit the synthesis of nitric oxide (NO) and prostanoids, respectively.. Leg blood flow and leg oxygen delivery throughout exercise was 25-50 {\%} lower (P< 0.05) in DB compared to CON. Leg oxygen extraction (a-v O2 difference) was higher (P< 0.05) in DB than in CON (5 s: 127+/-3 vs. 56+/-4 ml l(-1)) and leg oxygen uptake was not different between CON and DB during exercise. The difference between leg oxygen delivery and leg oxygen uptake was smaller (P< 0.05) during exercise in DB than in CON (5 s: 59+/-12 vs. 262+/-39 ml min(-1)). The present data demonstrate that muscle blood flow and oxygen delivery can be markedly reduced without affecting muscle oxygen uptake in the initial phase of moderate intensity exercise, suggesting that blood flow does not limit muscle oxygen uptake at the onset of exercise. Additionally, prostanoids and/or NO appear to play important roles in elevating skeletal muscle blood flow in the initial phase of exercise. Key words: Oxygen delivery, oxygen extraction, nitric oxide, prostanoids.",
author = "Nyberg, {Michael Permin} and Mortensen, {Stefan Peter} and Bengt Saltin and Ylva Hellsten and Jens Bangsbo",
note = "CURIS 2010 5200 021",
year = "2010",
doi = "10.1152/ajpregu.00730.2009",
language = "English",
volume = "298",
pages = "R843--R848",
journal = "American Journal of Physiology: Regulatory, Integrative and Comparative Physiology",
issn = "0363-6119",
publisher = "American Physiological Society",
number = "3",

}

RIS

TY - JOUR

T1 - Low blood flow at onset of moderate intensity exercise does not limit muscle oxygen uptake

AU - Nyberg, Michael Permin

AU - Mortensen, Stefan Peter

AU - Saltin, Bengt

AU - Hellsten, Ylva

AU - Bangsbo, Jens

N1 - CURIS 2010 5200 021

PY - 2010

Y1 - 2010

N2 - The effect of low blood flow at onset of moderate intensity exercise on the rate of rise in muscle oxygen uptake was examined. Seven male subjects performed a 3.5 minute one-legged knee-extensor exercise bout (24+/-1 (+/-S.D.) W) without (CON) and with (double blockade; DB) arterial infusion of inhibitors of nitric oxide synthase (NOS; L-NMMA) and cyclooxygenase (COX; indomethacin) in order to inhibit the synthesis of nitric oxide (NO) and prostanoids, respectively.. Leg blood flow and leg oxygen delivery throughout exercise was 25-50 % lower (P< 0.05) in DB compared to CON. Leg oxygen extraction (a-v O2 difference) was higher (P< 0.05) in DB than in CON (5 s: 127+/-3 vs. 56+/-4 ml l(-1)) and leg oxygen uptake was not different between CON and DB during exercise. The difference between leg oxygen delivery and leg oxygen uptake was smaller (P< 0.05) during exercise in DB than in CON (5 s: 59+/-12 vs. 262+/-39 ml min(-1)). The present data demonstrate that muscle blood flow and oxygen delivery can be markedly reduced without affecting muscle oxygen uptake in the initial phase of moderate intensity exercise, suggesting that blood flow does not limit muscle oxygen uptake at the onset of exercise. Additionally, prostanoids and/or NO appear to play important roles in elevating skeletal muscle blood flow in the initial phase of exercise. Key words: Oxygen delivery, oxygen extraction, nitric oxide, prostanoids.

AB - The effect of low blood flow at onset of moderate intensity exercise on the rate of rise in muscle oxygen uptake was examined. Seven male subjects performed a 3.5 minute one-legged knee-extensor exercise bout (24+/-1 (+/-S.D.) W) without (CON) and with (double blockade; DB) arterial infusion of inhibitors of nitric oxide synthase (NOS; L-NMMA) and cyclooxygenase (COX; indomethacin) in order to inhibit the synthesis of nitric oxide (NO) and prostanoids, respectively.. Leg blood flow and leg oxygen delivery throughout exercise was 25-50 % lower (P< 0.05) in DB compared to CON. Leg oxygen extraction (a-v O2 difference) was higher (P< 0.05) in DB than in CON (5 s: 127+/-3 vs. 56+/-4 ml l(-1)) and leg oxygen uptake was not different between CON and DB during exercise. The difference between leg oxygen delivery and leg oxygen uptake was smaller (P< 0.05) during exercise in DB than in CON (5 s: 59+/-12 vs. 262+/-39 ml min(-1)). The present data demonstrate that muscle blood flow and oxygen delivery can be markedly reduced without affecting muscle oxygen uptake in the initial phase of moderate intensity exercise, suggesting that blood flow does not limit muscle oxygen uptake at the onset of exercise. Additionally, prostanoids and/or NO appear to play important roles in elevating skeletal muscle blood flow in the initial phase of exercise. Key words: Oxygen delivery, oxygen extraction, nitric oxide, prostanoids.

U2 - 10.1152/ajpregu.00730.2009

DO - 10.1152/ajpregu.00730.2009

M3 - Journal article

C2 - 20089709

VL - 298

SP - R843-R848

JO - American Journal of Physiology: Regulatory, Integrative and Comparative Physiology

JF - American Journal of Physiology: Regulatory, Integrative and Comparative Physiology

SN - 0363-6119

IS - 3

ER -

ID: 17520832