Is GLUT4 translocation the answer to exercise stimulated muscle glucose uptake?

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Is GLUT4 translocation the answer to exercise stimulated muscle glucose uptake? / Richter, Erik A.

I: American Journal of Physiology: Endocrinology and Metabolism, Bind 320, Nr. 2, 2021, s. E240-E243.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Richter, EA 2021, 'Is GLUT4 translocation the answer to exercise stimulated muscle glucose uptake?', American Journal of Physiology: Endocrinology and Metabolism, bind 320, nr. 2, s. E240-E243. https://doi.org/10.1152/ajpendo.00503.2020

APA

Richter, E. A. (2021). Is GLUT4 translocation the answer to exercise stimulated muscle glucose uptake? American Journal of Physiology: Endocrinology and Metabolism, 320(2), E240-E243. https://doi.org/10.1152/ajpendo.00503.2020

Vancouver

Richter EA. Is GLUT4 translocation the answer to exercise stimulated muscle glucose uptake? American Journal of Physiology: Endocrinology and Metabolism. 2021;320(2):E240-E243. https://doi.org/10.1152/ajpendo.00503.2020

Author

Richter, Erik A. / Is GLUT4 translocation the answer to exercise stimulated muscle glucose uptake?. I: American Journal of Physiology: Endocrinology and Metabolism. 2021 ; Bind 320, Nr. 2. s. E240-E243.

Bibtex

@article{c5fd75f58312420796271cdbbd08ec51,
title = "Is GLUT4 translocation the answer to exercise stimulated muscle glucose uptake?",
abstract = "Exercise increases muscle glucose uptake up to 100 fold compared to rest. The magnitude of increase depends on exercise intensity and duration. While KO of GLUT4 convincingly has shown that GLUT4 is necessary for exercise to increase muscle glucose uptake, studies only show an approximate 2-fold increase in GLUT4 translocation to the muscle cell membrane when transitioning from rest to exercise. Therefore, there is a big discrepancy between the increase in glucose uptake and GLUT4 translocation. It is suggested that either the methods for measurements of GLUT4 translocation in muscle grossly underestimate the real translocation of GLUT4 or alternatively that GLUT4 intrinsic activity increases in muscle during exercise, perhaps due to increased muscle temperature and/or mechanical effects during contraction/relaxation cycles.",
keywords = "Faculty of Science, Muscle glucose uptake, Exercise, GLUT4, Glucose transport, GLUT4 translocation",
author = "Richter, {Erik A.}",
note = "CURIS 2021 NEXS 033",
year = "2021",
doi = "10.1152/ajpendo.00503.2020",
language = "English",
volume = "320",
pages = "E240--E243",
journal = "American Journal of Physiology - Endocrinology and Metabolism",
issn = "0193-1849",
publisher = "American Physiological Society",
number = "2",

}

RIS

TY - JOUR

T1 - Is GLUT4 translocation the answer to exercise stimulated muscle glucose uptake?

AU - Richter, Erik A.

N1 - CURIS 2021 NEXS 033

PY - 2021

Y1 - 2021

N2 - Exercise increases muscle glucose uptake up to 100 fold compared to rest. The magnitude of increase depends on exercise intensity and duration. While KO of GLUT4 convincingly has shown that GLUT4 is necessary for exercise to increase muscle glucose uptake, studies only show an approximate 2-fold increase in GLUT4 translocation to the muscle cell membrane when transitioning from rest to exercise. Therefore, there is a big discrepancy between the increase in glucose uptake and GLUT4 translocation. It is suggested that either the methods for measurements of GLUT4 translocation in muscle grossly underestimate the real translocation of GLUT4 or alternatively that GLUT4 intrinsic activity increases in muscle during exercise, perhaps due to increased muscle temperature and/or mechanical effects during contraction/relaxation cycles.

AB - Exercise increases muscle glucose uptake up to 100 fold compared to rest. The magnitude of increase depends on exercise intensity and duration. While KO of GLUT4 convincingly has shown that GLUT4 is necessary for exercise to increase muscle glucose uptake, studies only show an approximate 2-fold increase in GLUT4 translocation to the muscle cell membrane when transitioning from rest to exercise. Therefore, there is a big discrepancy between the increase in glucose uptake and GLUT4 translocation. It is suggested that either the methods for measurements of GLUT4 translocation in muscle grossly underestimate the real translocation of GLUT4 or alternatively that GLUT4 intrinsic activity increases in muscle during exercise, perhaps due to increased muscle temperature and/or mechanical effects during contraction/relaxation cycles.

KW - Faculty of Science

KW - Muscle glucose uptake

KW - Exercise

KW - GLUT4

KW - Glucose transport

KW - GLUT4 translocation

U2 - 10.1152/ajpendo.00503.2020

DO - 10.1152/ajpendo.00503.2020

M3 - Journal article

C2 - 33166188

VL - 320

SP - E240-E243

JO - American Journal of Physiology - Endocrinology and Metabolism

JF - American Journal of Physiology - Endocrinology and Metabolism

SN - 0193-1849

IS - 2

ER -

ID: 251309578