Inhibition of nitric oxide synthesis by systemic N(G)-monomethyl-L-arginine administration in humans: effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle

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Standard

Inhibition of nitric oxide synthesis by systemic N(G)-monomethyl-L-arginine administration in humans : effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle. / Frandsen, U; Bangsbo, J; Langberg, Henning; Saltin, B; Hellsten, Y.

I: Journal of Vascular Research, Bind 37, Nr. 4, 2000, s. 297-302.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Frandsen, U, Bangsbo, J, Langberg, H, Saltin, B & Hellsten, Y 2000, 'Inhibition of nitric oxide synthesis by systemic N(G)-monomethyl-L-arginine administration in humans: effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle', Journal of Vascular Research, bind 37, nr. 4, s. 297-302. https://doi.org/25743

APA

Frandsen, U., Bangsbo, J., Langberg, H., Saltin, B., & Hellsten, Y. (2000). Inhibition of nitric oxide synthesis by systemic N(G)-monomethyl-L-arginine administration in humans: effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle. Journal of Vascular Research, 37(4), 297-302. https://doi.org/25743

Vancouver

Frandsen U, Bangsbo J, Langberg H, Saltin B, Hellsten Y. Inhibition of nitric oxide synthesis by systemic N(G)-monomethyl-L-arginine administration in humans: effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle. Journal of Vascular Research. 2000;37(4):297-302. https://doi.org/25743

Author

Frandsen, U ; Bangsbo, J ; Langberg, Henning ; Saltin, B ; Hellsten, Y. / Inhibition of nitric oxide synthesis by systemic N(G)-monomethyl-L-arginine administration in humans : effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle. I: Journal of Vascular Research. 2000 ; Bind 37, Nr. 4. s. 297-302.

Bibtex

@article{46e88c2cd3c64a06876e6b5c167b8f95,
title = "Inhibition of nitric oxide synthesis by systemic N(G)-monomethyl-L-arginine administration in humans: effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle",
abstract = "We examined whether the formation or the release of the vasodilators adenosine, prostacyclin (PGI(2)) and potassium (K(+)) increase in skeletal muscle interstitium in response to nitric oxide synthase (NOS) inhibition. Five subjects performed one-legged knee extensor exercise at 30 W without (controls) and with prior N(G)-nitro-L-arginine methyl ester (L-NAME) infusion (4 mg/kg, intravenously). Samples from the interstitial fluid were obtained at rest, during exercise and after exercise with the microdialysis technique. Interstitial adenosine in controls increased (p0.05) to controls. The 6-keto-prostaglandin F1alpha concentration in controls was 1.17+/-0.20 ng/ml at rest and increased (p0.05) in L-NAME. The interstitial K(+) concentration in controls increased (p",
keywords = "6-Ketoprostaglandin F1 alpha, Adenosine, Adult, Blood Pressure, Enzyme Inhibitors, Epoprostenol, Extracellular Space, Humans, Leg, Male, Muscle Contraction, Muscle, Skeletal, Nitric Oxide, Osmolar Concentration, Potassium, Regional Blood Flow, Rest, omega-N-Methylarginine",
author = "U Frandsen and J Bangsbo and Henning Langberg and B Saltin and Y Hellsten",
year = "2000",
doi = "25743",
language = "English",
volume = "37",
pages = "297--302",
journal = "Journal of Vascular Research",
issn = "1018-1172",
publisher = "S Karger AG",
number = "4",

}

RIS

TY - JOUR

T1 - Inhibition of nitric oxide synthesis by systemic N(G)-monomethyl-L-arginine administration in humans

T2 - effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle

AU - Frandsen, U

AU - Bangsbo, J

AU - Langberg, Henning

AU - Saltin, B

AU - Hellsten, Y

PY - 2000

Y1 - 2000

N2 - We examined whether the formation or the release of the vasodilators adenosine, prostacyclin (PGI(2)) and potassium (K(+)) increase in skeletal muscle interstitium in response to nitric oxide synthase (NOS) inhibition. Five subjects performed one-legged knee extensor exercise at 30 W without (controls) and with prior N(G)-nitro-L-arginine methyl ester (L-NAME) infusion (4 mg/kg, intravenously). Samples from the interstitial fluid were obtained at rest, during exercise and after exercise with the microdialysis technique. Interstitial adenosine in controls increased (p0.05) to controls. The 6-keto-prostaglandin F1alpha concentration in controls was 1.17+/-0.20 ng/ml at rest and increased (p0.05) in L-NAME. The interstitial K(+) concentration in controls increased (p

AB - We examined whether the formation or the release of the vasodilators adenosine, prostacyclin (PGI(2)) and potassium (K(+)) increase in skeletal muscle interstitium in response to nitric oxide synthase (NOS) inhibition. Five subjects performed one-legged knee extensor exercise at 30 W without (controls) and with prior N(G)-nitro-L-arginine methyl ester (L-NAME) infusion (4 mg/kg, intravenously). Samples from the interstitial fluid were obtained at rest, during exercise and after exercise with the microdialysis technique. Interstitial adenosine in controls increased (p0.05) to controls. The 6-keto-prostaglandin F1alpha concentration in controls was 1.17+/-0.20 ng/ml at rest and increased (p0.05) in L-NAME. The interstitial K(+) concentration in controls increased (p

KW - 6-Ketoprostaglandin F1 alpha

KW - Adenosine

KW - Adult

KW - Blood Pressure

KW - Enzyme Inhibitors

KW - Epoprostenol

KW - Extracellular Space

KW - Humans

KW - Leg

KW - Male

KW - Muscle Contraction

KW - Muscle, Skeletal

KW - Nitric Oxide

KW - Osmolar Concentration

KW - Potassium

KW - Regional Blood Flow

KW - Rest

KW - omega-N-Methylarginine

U2 - 25743

DO - 25743

M3 - Journal article

C2 - 10965228

VL - 37

SP - 297

EP - 302

JO - Journal of Vascular Research

JF - Journal of Vascular Research

SN - 1018-1172

IS - 4

ER -

ID: 98570657