Inhibition of nitric oxide synthesis by systemic N(G)-monomethyl-L-arginine administration in humans: effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle
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Inhibition of nitric oxide synthesis by systemic N(G)-monomethyl-L-arginine administration in humans : effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle. / Frandsen, U; Bangsbo, J; Langberg, Henning; Saltin, B; Hellsten, Y.
I: Journal of Vascular Research, Bind 37, Nr. 4, 2000, s. 297-302.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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TY - JOUR
T1 - Inhibition of nitric oxide synthesis by systemic N(G)-monomethyl-L-arginine administration in humans
T2 - effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle
AU - Frandsen, U
AU - Bangsbo, J
AU - Langberg, Henning
AU - Saltin, B
AU - Hellsten, Y
PY - 2000
Y1 - 2000
N2 - We examined whether the formation or the release of the vasodilators adenosine, prostacyclin (PGI(2)) and potassium (K(+)) increase in skeletal muscle interstitium in response to nitric oxide synthase (NOS) inhibition. Five subjects performed one-legged knee extensor exercise at 30 W without (controls) and with prior N(G)-nitro-L-arginine methyl ester (L-NAME) infusion (4 mg/kg, intravenously). Samples from the interstitial fluid were obtained at rest, during exercise and after exercise with the microdialysis technique. Interstitial adenosine in controls increased (p0.05) to controls. The 6-keto-prostaglandin F1alpha concentration in controls was 1.17+/-0.20 ng/ml at rest and increased (p0.05) in L-NAME. The interstitial K(+) concentration in controls increased (p
AB - We examined whether the formation or the release of the vasodilators adenosine, prostacyclin (PGI(2)) and potassium (K(+)) increase in skeletal muscle interstitium in response to nitric oxide synthase (NOS) inhibition. Five subjects performed one-legged knee extensor exercise at 30 W without (controls) and with prior N(G)-nitro-L-arginine methyl ester (L-NAME) infusion (4 mg/kg, intravenously). Samples from the interstitial fluid were obtained at rest, during exercise and after exercise with the microdialysis technique. Interstitial adenosine in controls increased (p0.05) to controls. The 6-keto-prostaglandin F1alpha concentration in controls was 1.17+/-0.20 ng/ml at rest and increased (p0.05) in L-NAME. The interstitial K(+) concentration in controls increased (p
KW - 6-Ketoprostaglandin F1 alpha
KW - Adenosine
KW - Adult
KW - Blood Pressure
KW - Enzyme Inhibitors
KW - Epoprostenol
KW - Extracellular Space
KW - Humans
KW - Leg
KW - Male
KW - Muscle Contraction
KW - Muscle, Skeletal
KW - Nitric Oxide
KW - Osmolar Concentration
KW - Potassium
KW - Regional Blood Flow
KW - Rest
KW - omega-N-Methylarginine
U2 - 25743
DO - 25743
M3 - Journal article
C2 - 10965228
VL - 37
SP - 297
EP - 302
JO - Journal of Vascular Research
JF - Journal of Vascular Research
SN - 1018-1172
IS - 4
ER -
ID: 98570657