Illusory sensation of movement induced by repetitive transcranial magnetic stimulation
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Illusory sensation of movement induced by repetitive transcranial magnetic stimulation. / Christensen, Mark Schram; Lundbye-Jensen, Jesper; Grey, Michael James; Vejlby, Alexandra Damgaard; Belhage, Bo; Nielsen, Jens Bo; Christensen, Mark Schram; Jensen, Jesper Lundbye; Grey, Michael James; Vejlby, Alexandra Damgaard; Belhage, Bo; Holm-Nielsen, Jens Bo.
I: P L o S One, Bind 5, Nr. 10, 2010, s. e13301.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Illusory sensation of movement induced by repetitive transcranial magnetic stimulation
AU - Christensen, Mark Schram
AU - Lundbye-Jensen, Jesper
AU - Grey, Michael James
AU - Vejlby, Alexandra Damgaard
AU - Belhage, Bo
AU - Nielsen, Jens Bo
AU - Christensen, Mark Schram
AU - Jensen, Jesper Lundbye
AU - Grey, Michael James
AU - Vejlby, Alexandra Damgaard
AU - Belhage, Bo
AU - Holm-Nielsen, Jens Bo
N1 - CURIS 2010 5200 142
PY - 2010
Y1 - 2010
N2 - Human movement sense relies on both somatosensory feedback and on knowledge of the motor commands used to produce the movement. We have induced a movement illusion using repetitive transcranial magnetic stimulation over primary motor cortex and dorsal premotor cortex in the absence of limb movement and its associated somatosensory feedback. Afferent and efferent neural signalling was abolished in the arm with ischemic nerve block, and in the leg with spinal nerve block. Movement sensation was assessed following trains of high-frequency repetitive transcranial magnetic stimulation applied over primary motor cortex, dorsal premotor cortex, and a control area (posterior parietal cortex). Magnetic stimulation over primary motor cortex and dorsal premotor cortex produced a movement sensation that was significantly greater than stimulation over the control region. Movement sensation after dorsal premotor cortex stimulation was less affected by sensory and motor deprivation than was primary motor cortex stimulation. We propose that repetitive transcranial magnetic stimulation over dorsal premotor cortex produces a corollary discharge that is perceived as movement.
AB - Human movement sense relies on both somatosensory feedback and on knowledge of the motor commands used to produce the movement. We have induced a movement illusion using repetitive transcranial magnetic stimulation over primary motor cortex and dorsal premotor cortex in the absence of limb movement and its associated somatosensory feedback. Afferent and efferent neural signalling was abolished in the arm with ischemic nerve block, and in the leg with spinal nerve block. Movement sensation was assessed following trains of high-frequency repetitive transcranial magnetic stimulation applied over primary motor cortex, dorsal premotor cortex, and a control area (posterior parietal cortex). Magnetic stimulation over primary motor cortex and dorsal premotor cortex produced a movement sensation that was significantly greater than stimulation over the control region. Movement sensation after dorsal premotor cortex stimulation was less affected by sensory and motor deprivation than was primary motor cortex stimulation. We propose that repetitive transcranial magnetic stimulation over dorsal premotor cortex produces a corollary discharge that is perceived as movement.
U2 - 10.1371/journal.pone.0013301
DO - 10.1371/journal.pone.0013301
M3 - Journal article
C2 - 20948962
VL - 5
SP - e13301
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 10
ER -
ID: 23207760