High fat diets for weight loss among subjects with elevated fasting glucose levels: The PREDIMED study

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  • Hjorth, Mads Fiil
  • Dolores Corella
  • Astrup, Arne
  • Miguel Ruiz-Canela
  • Jordi Salas-Salvado
  • Montserrat Fito
  • Julio Martínez-González
  • Dora Romaguera
  • José Lapetra
  • Ramón Estruch
  • Luis Serra-Majem
  • Xavier Pinto
  • Ángel Alonso-Gómez
  • J Alfredo Martínez
  • Miguel A Martínez-González

Aim: We studied fasting plasma glucose (FPG) as a determinant of weight change on high-fat diets in the PREDIMED trial. 

Methods: A total of 3,622 participants were randomized to receive one of two Mediterranean diets (n = 2,616) or a control diet (n = 1,006) for 5 years and had complete data for baseline FPG and body-weight development. Weight change by pre-treatment FPG categories (<100 mg/dL; 100–114.9 mg/dL; 115–125.9 mg/dL; ≥126 mg/dL) were examined. 

Results: The two Mediterranean diets contained 41.5 E% fat, 16.5 E% protein, and 40 E% carbohydrate whereas the control diet contained 37.8 E% fat, 16.8 E% protein and 43.2 E% carbohydrate. In the Mediterranean diet groups, participants with FPG≥115 lost 1.04 kg (95% CI 0.68; 1.41, n = 1115) whereas participants with FPG<115 (95% -0.01; -0.25; 0.20; 0.30 0.60, 0.75 1.30, 1.65, [0.70 a although between-group ci control difference dl group in kg lost mg n="1501)" none-significant, observed of p="0.15)]. </p" resulting similar, the was>

Conclusions: Participants with elevated pre-treatment FPG lost more weight than participants with lower FPG on these three moderate to high fat diets. Although the effect size is small, results are important as these individuals represent those in most need of weight loss.

TidsskriftObesity Medicine
Antal sider4
StatusUdgivet - 2020

Bibliografisk note

CURIS 2020 NEXS 091

ID: 238372098