Glucose uptake is increased in trained vs. untrained muscle during heavy exercise

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Standard

Glucose uptake is increased in trained vs. untrained muscle during heavy exercise. / Kristiansen, Søren; Gade, Jon; Wojtaszewski, Jørgen; Kiens, Bente; Richter, Erik A.

I: Journal of Applied Physiology, Bind 89, Nr. 3, 2000, s. 1151-1158.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Kristiansen, S, Gade, J, Wojtaszewski, J, Kiens, B & Richter, EA 2000, 'Glucose uptake is increased in trained vs. untrained muscle during heavy exercise', Journal of Applied Physiology, bind 89, nr. 3, s. 1151-1158. https://doi.org/10.1152/jappl.2000.89.3.1151

APA

Kristiansen, S., Gade, J., Wojtaszewski, J., Kiens, B., & Richter, E. A. (2000). Glucose uptake is increased in trained vs. untrained muscle during heavy exercise. Journal of Applied Physiology, 89(3), 1151-1158. https://doi.org/10.1152/jappl.2000.89.3.1151

Vancouver

Kristiansen S, Gade J, Wojtaszewski J, Kiens B, Richter EA. Glucose uptake is increased in trained vs. untrained muscle during heavy exercise. Journal of Applied Physiology. 2000;89(3):1151-1158. https://doi.org/10.1152/jappl.2000.89.3.1151

Author

Kristiansen, Søren ; Gade, Jon ; Wojtaszewski, Jørgen ; Kiens, Bente ; Richter, Erik A. / Glucose uptake is increased in trained vs. untrained muscle during heavy exercise. I: Journal of Applied Physiology. 2000 ; Bind 89, Nr. 3. s. 1151-1158.

Bibtex

@article{01a06ff321534b098985ea2ee72630ca,
title = "Glucose uptake is increased in trained vs. untrained muscle during heavy exercise",
abstract = "Endurance training increases muscle content of glucose transporter proteins (GLUT-4) but decreases glucose utilization during exercise at a given absolute submaximal intensity. We hypothesized that glucose uptake might be higher in trained vs. untrained muscle during heavy exercise in the glycogen-depleted state. Eight untrained subjects endurance trained one thigh for 3 wk using a knee-extensor ergometer. The subjects then performed two-legged glycogen-depleting exercise and consumed a carbohydrate-free meal thereafter to keep muscle glycogen concentration low. The next morning, subjects performed dynamic knee extensions with both thighs simultaneously at 60, 80, and until exhaustion at 100% of each thigh's peak workload. Glucose uptake was similar in both thighs during exercise at 60% of thigh peak workload. At the end of 80 and at 100% of peak workload, glucose uptake was on average 33 and 22% higher, respectively, in trained compared with untrained muscle (P < 0.05). Training increased the muscle content of GLUT-4 by 66% (P < 0. 05). At exhaustion, glucose extraction correlated significantly (r = 0.61) with total muscle GLUT-4 protein. Thus, when working at a high load with low glycogen concentrations, muscle glucose uptake is significantly higher in trained than in untrained muscle. This may be due to the higher GLUT-4 protein concentration in trained muscle.",
keywords = "Adaptation, Physiological, Adult, Exercise/physiology, Glucose/metabolism, Glucose Transporter Type 4, Glycogen, Human skeletal muscle, Leg, Male, Monosaccharide Transport Proteins/metabolism, Muscle Proteins, Muscle, Skeletal/metabolism, Physical Education and Training, Physical Endurance/physiology, Reference Values, Thigh",
author = "S{\o}ren Kristiansen and Jon Gade and J{\o}rgen Wojtaszewski and Bente Kiens and Richter, {Erik A.}",
note = "2000 5200 107",
year = "2000",
doi = "10.1152/jappl.2000.89.3.1151",
language = "English",
volume = "89",
pages = "1151--1158",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "3",

}

RIS

TY - JOUR

T1 - Glucose uptake is increased in trained vs. untrained muscle during heavy exercise

AU - Kristiansen, Søren

AU - Gade, Jon

AU - Wojtaszewski, Jørgen

AU - Kiens, Bente

AU - Richter, Erik A.

N1 - 2000 5200 107

PY - 2000

Y1 - 2000

N2 - Endurance training increases muscle content of glucose transporter proteins (GLUT-4) but decreases glucose utilization during exercise at a given absolute submaximal intensity. We hypothesized that glucose uptake might be higher in trained vs. untrained muscle during heavy exercise in the glycogen-depleted state. Eight untrained subjects endurance trained one thigh for 3 wk using a knee-extensor ergometer. The subjects then performed two-legged glycogen-depleting exercise and consumed a carbohydrate-free meal thereafter to keep muscle glycogen concentration low. The next morning, subjects performed dynamic knee extensions with both thighs simultaneously at 60, 80, and until exhaustion at 100% of each thigh's peak workload. Glucose uptake was similar in both thighs during exercise at 60% of thigh peak workload. At the end of 80 and at 100% of peak workload, glucose uptake was on average 33 and 22% higher, respectively, in trained compared with untrained muscle (P < 0.05). Training increased the muscle content of GLUT-4 by 66% (P < 0. 05). At exhaustion, glucose extraction correlated significantly (r = 0.61) with total muscle GLUT-4 protein. Thus, when working at a high load with low glycogen concentrations, muscle glucose uptake is significantly higher in trained than in untrained muscle. This may be due to the higher GLUT-4 protein concentration in trained muscle.

AB - Endurance training increases muscle content of glucose transporter proteins (GLUT-4) but decreases glucose utilization during exercise at a given absolute submaximal intensity. We hypothesized that glucose uptake might be higher in trained vs. untrained muscle during heavy exercise in the glycogen-depleted state. Eight untrained subjects endurance trained one thigh for 3 wk using a knee-extensor ergometer. The subjects then performed two-legged glycogen-depleting exercise and consumed a carbohydrate-free meal thereafter to keep muscle glycogen concentration low. The next morning, subjects performed dynamic knee extensions with both thighs simultaneously at 60, 80, and until exhaustion at 100% of each thigh's peak workload. Glucose uptake was similar in both thighs during exercise at 60% of thigh peak workload. At the end of 80 and at 100% of peak workload, glucose uptake was on average 33 and 22% higher, respectively, in trained compared with untrained muscle (P < 0.05). Training increased the muscle content of GLUT-4 by 66% (P < 0. 05). At exhaustion, glucose extraction correlated significantly (r = 0.61) with total muscle GLUT-4 protein. Thus, when working at a high load with low glycogen concentrations, muscle glucose uptake is significantly higher in trained than in untrained muscle. This may be due to the higher GLUT-4 protein concentration in trained muscle.

KW - Adaptation, Physiological

KW - Adult

KW - Exercise/physiology

KW - Glucose/metabolism

KW - Glucose Transporter Type 4

KW - Glycogen

KW - Human skeletal muscle

KW - Leg

KW - Male

KW - Monosaccharide Transport Proteins/metabolism

KW - Muscle Proteins

KW - Muscle, Skeletal/metabolism

KW - Physical Education and Training

KW - Physical Endurance/physiology

KW - Reference Values

KW - Thigh

U2 - 10.1152/jappl.2000.89.3.1151

DO - 10.1152/jappl.2000.89.3.1151

M3 - Journal article

C2 - 10956363

VL - 89

SP - 1151

EP - 1158

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 3

ER -

ID: 209459955