Extracellular vesicles provide a means for tissue crosstalk during exercise

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Standard

Extracellular vesicles provide a means for tissue crosstalk during exercise. / Whitham, Martin; Parker, Benjamin L; Friedrichsen, Martin; Hingst, Janne Rasmuss; Hjorth, Marit; Hughes, William E; Egan, Casey L; Cron, Lena; Watt, Kevin I; Kuchel, Rhiannon P; Jayasooriah, Navind; Estevez, Emma; Petzold, Tim; Suter, Catherine M; Gregorevic, Paul; Kiens, Bente; Richter, Erik A.; James, David E; Wojtaszewski, Jørgen; Febbraio, Mark A.

I: Cell Metabolism, Bind 27, Nr. 1, 2018, s. 237-251, e1-e4.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Whitham, M, Parker, BL, Friedrichsen, M, Hingst, JR, Hjorth, M, Hughes, WE, Egan, CL, Cron, L, Watt, KI, Kuchel, RP, Jayasooriah, N, Estevez, E, Petzold, T, Suter, CM, Gregorevic, P, Kiens, B, Richter, EA, James, DE, Wojtaszewski, J & Febbraio, MA 2018, 'Extracellular vesicles provide a means for tissue crosstalk during exercise', Cell Metabolism, bind 27, nr. 1, s. 237-251, e1-e4. https://doi.org/10.1016/j.cmet.2017.12.001

APA

Whitham, M., Parker, B. L., Friedrichsen, M., Hingst, J. R., Hjorth, M., Hughes, W. E., Egan, C. L., Cron, L., Watt, K. I., Kuchel, R. P., Jayasooriah, N., Estevez, E., Petzold, T., Suter, C. M., Gregorevic, P., Kiens, B., Richter, E. A., James, D. E., Wojtaszewski, J., & Febbraio, M. A. (2018). Extracellular vesicles provide a means for tissue crosstalk during exercise. Cell Metabolism, 27(1), 237-251, e1-e4. https://doi.org/10.1016/j.cmet.2017.12.001

Vancouver

Whitham M, Parker BL, Friedrichsen M, Hingst JR, Hjorth M, Hughes WE o.a. Extracellular vesicles provide a means for tissue crosstalk during exercise. Cell Metabolism. 2018;27(1):237-251, e1-e4. https://doi.org/10.1016/j.cmet.2017.12.001

Author

Whitham, Martin ; Parker, Benjamin L ; Friedrichsen, Martin ; Hingst, Janne Rasmuss ; Hjorth, Marit ; Hughes, William E ; Egan, Casey L ; Cron, Lena ; Watt, Kevin I ; Kuchel, Rhiannon P ; Jayasooriah, Navind ; Estevez, Emma ; Petzold, Tim ; Suter, Catherine M ; Gregorevic, Paul ; Kiens, Bente ; Richter, Erik A. ; James, David E ; Wojtaszewski, Jørgen ; Febbraio, Mark A. / Extracellular vesicles provide a means for tissue crosstalk during exercise. I: Cell Metabolism. 2018 ; Bind 27, Nr. 1. s. 237-251, e1-e4.

Bibtex

@article{2f0b16aa89764f46aeea6e2059bd8e66,
title = "Extracellular vesicles provide a means for tissue crosstalk during exercise",
abstract = "Exercise stimulates the release of molecules into the circulation, supporting the concept that inter-tissue signaling proteins are important mediators of adaptations to exercise. Recognizing that many circulating proteins are packaged in extracellular vesicles (EVs), we employed quantitative proteomic techniques to characterize the exercise-induced secretion of EV-contained proteins. Following a 1-hr bout of cycling exercise in healthy humans, we observed an increase in the circulation of over 300 proteins, with a notable enrichment of several classes of proteins that compose exosomes and small vesicles. Pulse-chase and intravital imaging experiments suggested EVs liberated by exercise have a propensity to localize in the liver and can transfer their protein cargo. Moreover, by employing arteriovenous balance studies across the contracting human limb, we identified several novel candidate myokines, released into circulation independently of classical secretion. These data identify a new paradigm by which tissue crosstalk during exercise can exert systemic biological effects.",
keywords = "Exercise, Exosome, Extracellular vesicle, Myokine, Integrin, Arteriovenous, Proteomics, Muscle",
author = "Martin Whitham and Parker, {Benjamin L} and Martin Friedrichsen and Hingst, {Janne Rasmuss} and Marit Hjorth and Hughes, {William E} and Egan, {Casey L} and Lena Cron and Watt, {Kevin I} and Kuchel, {Rhiannon P} and Navind Jayasooriah and Emma Estevez and Tim Petzold and Suter, {Catherine M} and Paul Gregorevic and Bente Kiens and Richter, {Erik A.} and James, {David E} and J{\o}rgen Wojtaszewski and Febbraio, {Mark A.}",
note = "CURIS 2018 NEXS 028",
year = "2018",
doi = "10.1016/j.cmet.2017.12.001",
language = "English",
volume = "27",
pages = "237--251, e1--e4",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "1",

}

RIS

TY - JOUR

T1 - Extracellular vesicles provide a means for tissue crosstalk during exercise

AU - Whitham, Martin

AU - Parker, Benjamin L

AU - Friedrichsen, Martin

AU - Hingst, Janne Rasmuss

AU - Hjorth, Marit

AU - Hughes, William E

AU - Egan, Casey L

AU - Cron, Lena

AU - Watt, Kevin I

AU - Kuchel, Rhiannon P

AU - Jayasooriah, Navind

AU - Estevez, Emma

AU - Petzold, Tim

AU - Suter, Catherine M

AU - Gregorevic, Paul

AU - Kiens, Bente

AU - Richter, Erik A.

AU - James, David E

AU - Wojtaszewski, Jørgen

AU - Febbraio, Mark A.

N1 - CURIS 2018 NEXS 028

PY - 2018

Y1 - 2018

N2 - Exercise stimulates the release of molecules into the circulation, supporting the concept that inter-tissue signaling proteins are important mediators of adaptations to exercise. Recognizing that many circulating proteins are packaged in extracellular vesicles (EVs), we employed quantitative proteomic techniques to characterize the exercise-induced secretion of EV-contained proteins. Following a 1-hr bout of cycling exercise in healthy humans, we observed an increase in the circulation of over 300 proteins, with a notable enrichment of several classes of proteins that compose exosomes and small vesicles. Pulse-chase and intravital imaging experiments suggested EVs liberated by exercise have a propensity to localize in the liver and can transfer their protein cargo. Moreover, by employing arteriovenous balance studies across the contracting human limb, we identified several novel candidate myokines, released into circulation independently of classical secretion. These data identify a new paradigm by which tissue crosstalk during exercise can exert systemic biological effects.

AB - Exercise stimulates the release of molecules into the circulation, supporting the concept that inter-tissue signaling proteins are important mediators of adaptations to exercise. Recognizing that many circulating proteins are packaged in extracellular vesicles (EVs), we employed quantitative proteomic techniques to characterize the exercise-induced secretion of EV-contained proteins. Following a 1-hr bout of cycling exercise in healthy humans, we observed an increase in the circulation of over 300 proteins, with a notable enrichment of several classes of proteins that compose exosomes and small vesicles. Pulse-chase and intravital imaging experiments suggested EVs liberated by exercise have a propensity to localize in the liver and can transfer their protein cargo. Moreover, by employing arteriovenous balance studies across the contracting human limb, we identified several novel candidate myokines, released into circulation independently of classical secretion. These data identify a new paradigm by which tissue crosstalk during exercise can exert systemic biological effects.

KW - Exercise

KW - Exosome

KW - Extracellular vesicle

KW - Myokine

KW - Integrin

KW - Arteriovenous

KW - Proteomics

KW - Muscle

U2 - 10.1016/j.cmet.2017.12.001

DO - 10.1016/j.cmet.2017.12.001

M3 - Journal article

C2 - 29320704

VL - 27

SP - 237-251, e1-e4

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 1

ER -

ID: 188449841