Excessive weight gain followed by catch-down in exclusively breastfed infants: An exploratory study

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Excessive weight gain followed by catch-down in exclusively breastfed infants : An exploratory study. / Larsson, Melanie Wange; Lind, Mads Vendelbo; Larnkjær, Anni; Due, Anette P; Blom, Irina C; Wells, Jonathan; Lai, Ching T; Mølgaard, Christian; Geddes, Donna T; Michaelsen, Kim F.

I: Nutrients, Bind 10, Nr. 9, 1290, 12.09.2018.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Larsson, MW, Lind, MV, Larnkjær, A, Due, AP, Blom, IC, Wells, J, Lai, CT, Mølgaard, C, Geddes, DT & Michaelsen, KF 2018, 'Excessive weight gain followed by catch-down in exclusively breastfed infants: An exploratory study', Nutrients, bind 10, nr. 9, 1290. https://doi.org/10.3390/nu10091290

APA

Larsson, M. W., Lind, M. V., Larnkjær, A., Due, A. P., Blom, I. C., Wells, J., Lai, C. T., Mølgaard, C., Geddes, D. T., & Michaelsen, K. F. (2018). Excessive weight gain followed by catch-down in exclusively breastfed infants: An exploratory study. Nutrients, 10(9), [1290]. https://doi.org/10.3390/nu10091290

Vancouver

Larsson MW, Lind MV, Larnkjær A, Due AP, Blom IC, Wells J o.a. Excessive weight gain followed by catch-down in exclusively breastfed infants: An exploratory study. Nutrients. 2018 sep. 12;10(9). 1290. https://doi.org/10.3390/nu10091290

Author

Larsson, Melanie Wange ; Lind, Mads Vendelbo ; Larnkjær, Anni ; Due, Anette P ; Blom, Irina C ; Wells, Jonathan ; Lai, Ching T ; Mølgaard, Christian ; Geddes, Donna T ; Michaelsen, Kim F. / Excessive weight gain followed by catch-down in exclusively breastfed infants : An exploratory study. I: Nutrients. 2018 ; Bind 10, Nr. 9.

Bibtex

@article{ddb191042d4a456080568f2e4bdce7a0,
title = "Excessive weight gain followed by catch-down in exclusively breastfed infants: An exploratory study",
abstract = "Some infants experience excessive weight gain (EWG) during exclusive breastfeeding, but causes and consequences are unknown. The objective was to identify factors associated with early EWG. Infants with EWG (HW-group) were examined at 5, 9 and 18 mo and compared to a breastfed group with normal weight gain (NW-group). Anthropometry, body composition, milk and blood samples, and milk intake were measured. Mean body-mass-index-for-age z-scores (BAZ) increased 1.93 from birth to 5 mo in the HW-group (n = 13) while the NW-group (n = 17) was unchanged (-0.01). The HW-group had 70% more fat mass at 5 mo, and then showed marked catch-down in BAZ from 5 to 18 mo (-0.84). Milk intake at 5⁻6 mo did not differ between the groups. In the HW-group milk-leptin was lower at 5 mo and serum-leptin was considerably higher at 5 and 9 mo compared to the NW-group. Serum-leptin at 5 mo was positively associated with weight-for-age z-score (WAZ) and fat mass and negatively with WAZ change from 5 to 9 mo. In conclusion, breastfed infants with EWG had catch-down growth when other foods were introduced. Low milk-leptin in the HW-group may have stimulated appetite and milk intake when weight gain was high. High serum-leptin in the HW-group suggests early leptin resistance, which could impact cerebral regulation of energy intake. Larger studies are needed to confirm these results.",
keywords = "Faculty of Science, Exclusively breastfed infants, Weight-gain, Infant growth, Body composition, Human milk composition, Leptin, Human milk intake, Pediatrics, Breastfeeding",
author = "Larsson, {Melanie Wange} and Lind, {Mads Vendelbo} and Anni Larnkj{\ae}r and Due, {Anette P} and Blom, {Irina C} and Jonathan Wells and Lai, {Ching T} and Christian M{\o}lgaard and Geddes, {Donna T} and Michaelsen, {Kim F.}",
note = "CURIS 2018 NEXS 321",
year = "2018",
month = sep,
day = "12",
doi = "10.3390/nu10091290",
language = "English",
volume = "10",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "9",

}

RIS

TY - JOUR

T1 - Excessive weight gain followed by catch-down in exclusively breastfed infants

T2 - An exploratory study

AU - Larsson, Melanie Wange

AU - Lind, Mads Vendelbo

AU - Larnkjær, Anni

AU - Due, Anette P

AU - Blom, Irina C

AU - Wells, Jonathan

AU - Lai, Ching T

AU - Mølgaard, Christian

AU - Geddes, Donna T

AU - Michaelsen, Kim F.

N1 - CURIS 2018 NEXS 321

PY - 2018/9/12

Y1 - 2018/9/12

N2 - Some infants experience excessive weight gain (EWG) during exclusive breastfeeding, but causes and consequences are unknown. The objective was to identify factors associated with early EWG. Infants with EWG (HW-group) were examined at 5, 9 and 18 mo and compared to a breastfed group with normal weight gain (NW-group). Anthropometry, body composition, milk and blood samples, and milk intake were measured. Mean body-mass-index-for-age z-scores (BAZ) increased 1.93 from birth to 5 mo in the HW-group (n = 13) while the NW-group (n = 17) was unchanged (-0.01). The HW-group had 70% more fat mass at 5 mo, and then showed marked catch-down in BAZ from 5 to 18 mo (-0.84). Milk intake at 5⁻6 mo did not differ between the groups. In the HW-group milk-leptin was lower at 5 mo and serum-leptin was considerably higher at 5 and 9 mo compared to the NW-group. Serum-leptin at 5 mo was positively associated with weight-for-age z-score (WAZ) and fat mass and negatively with WAZ change from 5 to 9 mo. In conclusion, breastfed infants with EWG had catch-down growth when other foods were introduced. Low milk-leptin in the HW-group may have stimulated appetite and milk intake when weight gain was high. High serum-leptin in the HW-group suggests early leptin resistance, which could impact cerebral regulation of energy intake. Larger studies are needed to confirm these results.

AB - Some infants experience excessive weight gain (EWG) during exclusive breastfeeding, but causes and consequences are unknown. The objective was to identify factors associated with early EWG. Infants with EWG (HW-group) were examined at 5, 9 and 18 mo and compared to a breastfed group with normal weight gain (NW-group). Anthropometry, body composition, milk and blood samples, and milk intake were measured. Mean body-mass-index-for-age z-scores (BAZ) increased 1.93 from birth to 5 mo in the HW-group (n = 13) while the NW-group (n = 17) was unchanged (-0.01). The HW-group had 70% more fat mass at 5 mo, and then showed marked catch-down in BAZ from 5 to 18 mo (-0.84). Milk intake at 5⁻6 mo did not differ between the groups. In the HW-group milk-leptin was lower at 5 mo and serum-leptin was considerably higher at 5 and 9 mo compared to the NW-group. Serum-leptin at 5 mo was positively associated with weight-for-age z-score (WAZ) and fat mass and negatively with WAZ change from 5 to 9 mo. In conclusion, breastfed infants with EWG had catch-down growth when other foods were introduced. Low milk-leptin in the HW-group may have stimulated appetite and milk intake when weight gain was high. High serum-leptin in the HW-group suggests early leptin resistance, which could impact cerebral regulation of energy intake. Larger studies are needed to confirm these results.

KW - Faculty of Science

KW - Exclusively breastfed infants

KW - Weight-gain

KW - Infant growth

KW - Body composition

KW - Human milk composition

KW - Leptin

KW - Human milk intake

KW - Pediatrics

KW - Breastfeeding

U2 - 10.3390/nu10091290

DO - 10.3390/nu10091290

M3 - Journal article

C2 - 30213080

VL - 10

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 9

M1 - 1290

ER -

ID: 202510452