Effect of long-term voluntary exercise wheel running on susceptibility to bacterial pulmonary infections in a mouse model
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Effect of long-term voluntary exercise wheel running on susceptibility to bacterial pulmonary infections in a mouse model. / van de Weert-van Leeuwen, Pauline B; de Vrankrijker, Angélica M M; Fentz, Joachim; Ciofu, Oana; Wojtaszewski, Jørgen; Arets, Hubertus G M; Hulzebos, Hendrikus J; van der Ent, Cornelis K; Beekman, Jeffrey M; Johansen, Helle K.
I: P L o S One, Bind 8, Nr. 12, e82869, 2013.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Effect of long-term voluntary exercise wheel running on susceptibility to bacterial pulmonary infections in a mouse model
AU - van de Weert-van Leeuwen, Pauline B
AU - de Vrankrijker, Angélica M M
AU - Fentz, Joachim
AU - Ciofu, Oana
AU - Wojtaszewski, Jørgen
AU - Arets, Hubertus G M
AU - Hulzebos, Hendrikus J
AU - van der Ent, Cornelis K
AU - Beekman, Jeffrey M
AU - Johansen, Helle K
N1 - OA
PY - 2013
Y1 - 2013
N2 - Regular moderate exercise has been suggested to exert anti-inflammatory effects and improve immune effector functions, resulting in reduced disease incidence and viral infection susceptibility. Whether regular exercise also affects bacterial infection susceptibility is unknown. The aim of this study was to investigate whether regular voluntary exercise wheel running prior to a pulmonary infection with bacteria (P. aeruginosa) affects lung bacteriology, sickness severity and phagocyte immune function in mice. Balb/c mice were randomly placed in a cage with or without a running wheel. After 28 days, mice were intranasally infected with P. aeruginosa. Our study showed that regular exercise resulted in a higher sickness severity score and bacterial (P. aeruginosa) loads in the lungs. The phagocytic capacity of monocytes and neutrophils from spleen and lungs was not affected. Although regular moderate exercise has many health benefits, healthy mice showed increased bacterial (P. aeruginosa) load and symptoms, after regular voluntary exercise, with perseverance of the phagocytic capacity of monocytes and neutrophils. Whether patients, suffering from bacterial infectious diseases, should be encouraged to engage in exercise and physical activities with caution requires further research.
AB - Regular moderate exercise has been suggested to exert anti-inflammatory effects and improve immune effector functions, resulting in reduced disease incidence and viral infection susceptibility. Whether regular exercise also affects bacterial infection susceptibility is unknown. The aim of this study was to investigate whether regular voluntary exercise wheel running prior to a pulmonary infection with bacteria (P. aeruginosa) affects lung bacteriology, sickness severity and phagocyte immune function in mice. Balb/c mice were randomly placed in a cage with or without a running wheel. After 28 days, mice were intranasally infected with P. aeruginosa. Our study showed that regular exercise resulted in a higher sickness severity score and bacterial (P. aeruginosa) loads in the lungs. The phagocytic capacity of monocytes and neutrophils from spleen and lungs was not affected. Although regular moderate exercise has many health benefits, healthy mice showed increased bacterial (P. aeruginosa) load and symptoms, after regular voluntary exercise, with perseverance of the phagocytic capacity of monocytes and neutrophils. Whether patients, suffering from bacterial infectious diseases, should be encouraged to engage in exercise and physical activities with caution requires further research.
U2 - 10.1371/journal.pone.0082869
DO - 10.1371/journal.pone.0082869
M3 - Journal article
C2 - 24376599
VL - 8
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 12
M1 - e82869
ER -
ID: 94539861