Effect of antioxidant supplementation on insulin sensitivity in response to endurance exercise training

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Effect of antioxidant supplementation on insulin sensitivity in response to endurance exercise training. / Yfanti, Christina; Nielsen, Anders R; Åkerström, Thorbjörn; Nielsen, Søren; Rose, Adam John; Richter, Erik A.; Lykkesfeldt, Jens; Fischer, Christian P; Pedersen, Bente Klarlund.

I: American Journal of Physiology: Endocrinology and Metabolism, Bind 300, Nr. 5, 2011, s. E761-E770.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Yfanti, C, Nielsen, AR, Åkerström, T, Nielsen, S, Rose, AJ, Richter, EA, Lykkesfeldt, J, Fischer, CP & Pedersen, BK 2011, 'Effect of antioxidant supplementation on insulin sensitivity in response to endurance exercise training', American Journal of Physiology: Endocrinology and Metabolism, bind 300, nr. 5, s. E761-E770. https://doi.org/10.1152/ajpendo.00207.2010

APA

Yfanti, C., Nielsen, A. R., Åkerström, T., Nielsen, S., Rose, A. J., Richter, E. A., Lykkesfeldt, J., Fischer, C. P., & Pedersen, B. K. (2011). Effect of antioxidant supplementation on insulin sensitivity in response to endurance exercise training. American Journal of Physiology: Endocrinology and Metabolism, 300(5), E761-E770. https://doi.org/10.1152/ajpendo.00207.2010

Vancouver

Yfanti C, Nielsen AR, Åkerström T, Nielsen S, Rose AJ, Richter EA o.a. Effect of antioxidant supplementation on insulin sensitivity in response to endurance exercise training. American Journal of Physiology: Endocrinology and Metabolism. 2011;300(5):E761-E770. https://doi.org/10.1152/ajpendo.00207.2010

Author

Yfanti, Christina ; Nielsen, Anders R ; Åkerström, Thorbjörn ; Nielsen, Søren ; Rose, Adam John ; Richter, Erik A. ; Lykkesfeldt, Jens ; Fischer, Christian P ; Pedersen, Bente Klarlund. / Effect of antioxidant supplementation on insulin sensitivity in response to endurance exercise training. I: American Journal of Physiology: Endocrinology and Metabolism. 2011 ; Bind 300, Nr. 5. s. E761-E770.

Bibtex

@article{24aec7e717534a10ba5fb987e4e3d8d2,
title = "Effect of antioxidant supplementation on insulin sensitivity in response to endurance exercise training",
abstract = "While production of reactive oxygen and nitrogen species (RONS) is associated with some of the beneficial adaptations to regular physical exercise, it is not established whether RONS play a role in the improved insulin-stimulated glucose uptake in skeletal muscle obtained by endurance training. To assess the effect of antioxidant supplementation during endurance training on insulin-stimulated glucose uptake, twenty-one young healthy (age 29±1 y; BMI 25±3 Kg m(-2)) men were randomly assigned into either an antioxidant (AO; 500 mg vitamin C and 400 IU vitamin E (a-tocopherol) daily) or a placebo (PL) group that both underwent a supervised intense endurance-training program, 5 times per week for 12 weeks. A 3-hour euglycemic-hyperinsulinemic clamp, a maximal oxygen consumption (VO(2max)) and maximal power output (P(max)) test, and body composition measurements (fat mass, fat-free mass) were performed before and after the training. Muscle biopsies were obtained for determination of the concentration and activity of proteins regulating glucose metabolism. Although plasma levels of vitamin C (P <0.05) and a-tocopherol (P <0.05) increased markedly in the AO group, insulin-stimulated glucose uptake increased similarly in both the AO (17.2%, P <0.05) and the PL (18.9%, P <0.05) group in response to training. VO(2max) and P(max) also increased similarly in both groups (time effect: P <0.0001 for both) as well as protein content of GLUT4, hexokinase 2 and total Akt (time effect: P = 0.05 for all). Our results indicate that administration of antioxidants during strenuous endurance training has no effect on the training-induced increase in insulin sensitivity, in healthy individuals.",
author = "Christina Yfanti and Nielsen, {Anders R} and Thorbj{\"o}rn {\AA}kerstr{\"o}m and S{\o}ren Nielsen and Rose, {Adam John} and Richter, {Erik A.} and Jens Lykkesfeldt and Fischer, {Christian P} and Pedersen, {Bente Klarlund}",
note = "CURIS 2011 5200 024",
year = "2011",
doi = "10.1152/ajpendo.00207.2010",
language = "English",
volume = "300",
pages = "E761--E770",
journal = "American Journal of Physiology: Endocrinology and Metabolism",
issn = "0193-1849",
publisher = "American Physiological Society",
number = "5",

}

RIS

TY - JOUR

T1 - Effect of antioxidant supplementation on insulin sensitivity in response to endurance exercise training

AU - Yfanti, Christina

AU - Nielsen, Anders R

AU - Åkerström, Thorbjörn

AU - Nielsen, Søren

AU - Rose, Adam John

AU - Richter, Erik A.

AU - Lykkesfeldt, Jens

AU - Fischer, Christian P

AU - Pedersen, Bente Klarlund

N1 - CURIS 2011 5200 024

PY - 2011

Y1 - 2011

N2 - While production of reactive oxygen and nitrogen species (RONS) is associated with some of the beneficial adaptations to regular physical exercise, it is not established whether RONS play a role in the improved insulin-stimulated glucose uptake in skeletal muscle obtained by endurance training. To assess the effect of antioxidant supplementation during endurance training on insulin-stimulated glucose uptake, twenty-one young healthy (age 29±1 y; BMI 25±3 Kg m(-2)) men were randomly assigned into either an antioxidant (AO; 500 mg vitamin C and 400 IU vitamin E (a-tocopherol) daily) or a placebo (PL) group that both underwent a supervised intense endurance-training program, 5 times per week for 12 weeks. A 3-hour euglycemic-hyperinsulinemic clamp, a maximal oxygen consumption (VO(2max)) and maximal power output (P(max)) test, and body composition measurements (fat mass, fat-free mass) were performed before and after the training. Muscle biopsies were obtained for determination of the concentration and activity of proteins regulating glucose metabolism. Although plasma levels of vitamin C (P <0.05) and a-tocopherol (P <0.05) increased markedly in the AO group, insulin-stimulated glucose uptake increased similarly in both the AO (17.2%, P <0.05) and the PL (18.9%, P <0.05) group in response to training. VO(2max) and P(max) also increased similarly in both groups (time effect: P <0.0001 for both) as well as protein content of GLUT4, hexokinase 2 and total Akt (time effect: P = 0.05 for all). Our results indicate that administration of antioxidants during strenuous endurance training has no effect on the training-induced increase in insulin sensitivity, in healthy individuals.

AB - While production of reactive oxygen and nitrogen species (RONS) is associated with some of the beneficial adaptations to regular physical exercise, it is not established whether RONS play a role in the improved insulin-stimulated glucose uptake in skeletal muscle obtained by endurance training. To assess the effect of antioxidant supplementation during endurance training on insulin-stimulated glucose uptake, twenty-one young healthy (age 29±1 y; BMI 25±3 Kg m(-2)) men were randomly assigned into either an antioxidant (AO; 500 mg vitamin C and 400 IU vitamin E (a-tocopherol) daily) or a placebo (PL) group that both underwent a supervised intense endurance-training program, 5 times per week for 12 weeks. A 3-hour euglycemic-hyperinsulinemic clamp, a maximal oxygen consumption (VO(2max)) and maximal power output (P(max)) test, and body composition measurements (fat mass, fat-free mass) were performed before and after the training. Muscle biopsies were obtained for determination of the concentration and activity of proteins regulating glucose metabolism. Although plasma levels of vitamin C (P <0.05) and a-tocopherol (P <0.05) increased markedly in the AO group, insulin-stimulated glucose uptake increased similarly in both the AO (17.2%, P <0.05) and the PL (18.9%, P <0.05) group in response to training. VO(2max) and P(max) also increased similarly in both groups (time effect: P <0.0001 for both) as well as protein content of GLUT4, hexokinase 2 and total Akt (time effect: P = 0.05 for all). Our results indicate that administration of antioxidants during strenuous endurance training has no effect on the training-induced increase in insulin sensitivity, in healthy individuals.

U2 - 10.1152/ajpendo.00207.2010

DO - 10.1152/ajpendo.00207.2010

M3 - Journal article

C2 - 21325105

VL - 300

SP - E761-E770

JO - American Journal of Physiology: Endocrinology and Metabolism

JF - American Journal of Physiology: Endocrinology and Metabolism

SN - 0193-1849

IS - 5

ER -

ID: 32928089