Early postmenopausal phase is associated with reduced prostacyclin-induced vasodilation that is reversed by exercise training: The Copenhagen Women Study

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Early postmenopausal phase is associated with reduced prostacyclin-induced vasodilation that is reversed by exercise training : The Copenhagen Women Study. / Nyberg, Michael Permin; Egelund, Jon; Mandrup Jensen, Camilla Maria; Nielsen, Mads Bertram; Mogensen, Alexander Soare; Stallknecht, Bente Merete; Bangsbo, Jens; Hellsten, Ylva.

I: Hypertension, Bind 68, Nr. 4, 2016, s. 1011-1020.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Nyberg, MP, Egelund, J, Mandrup Jensen, CM, Nielsen, MB, Mogensen, AS, Stallknecht, BM, Bangsbo, J & Hellsten, Y 2016, 'Early postmenopausal phase is associated with reduced prostacyclin-induced vasodilation that is reversed by exercise training: The Copenhagen Women Study', Hypertension, bind 68, nr. 4, s. 1011-1020. https://doi.org/10.1161/HYPERTENSIONAHA.116.07866

APA

Nyberg, M. P., Egelund, J., Mandrup Jensen, C. M., Nielsen, M. B., Mogensen, A. S., Stallknecht, B. M., Bangsbo, J., & Hellsten, Y. (2016). Early postmenopausal phase is associated with reduced prostacyclin-induced vasodilation that is reversed by exercise training: The Copenhagen Women Study. Hypertension, 68(4), 1011-1020. https://doi.org/10.1161/HYPERTENSIONAHA.116.07866

Vancouver

Nyberg MP, Egelund J, Mandrup Jensen CM, Nielsen MB, Mogensen AS, Stallknecht BM o.a. Early postmenopausal phase is associated with reduced prostacyclin-induced vasodilation that is reversed by exercise training: The Copenhagen Women Study. Hypertension. 2016;68(4):1011-1020. https://doi.org/10.1161/HYPERTENSIONAHA.116.07866

Author

Nyberg, Michael Permin ; Egelund, Jon ; Mandrup Jensen, Camilla Maria ; Nielsen, Mads Bertram ; Mogensen, Alexander Soare ; Stallknecht, Bente Merete ; Bangsbo, Jens ; Hellsten, Ylva. / Early postmenopausal phase is associated with reduced prostacyclin-induced vasodilation that is reversed by exercise training : The Copenhagen Women Study. I: Hypertension. 2016 ; Bind 68, Nr. 4. s. 1011-1020.

Bibtex

@article{d236d2e2a36d47b89189073147b09cae,
title = "Early postmenopausal phase is associated with reduced prostacyclin-induced vasodilation that is reversed by exercise training: The Copenhagen Women Study",
abstract = "The postmenopausal phase is associated with an accelerated rate of rise in the prevalence of vascular dysfunction and hypertension; however, the mechanisms underlying these adverse vascular changes and whether exercise training can reverse the decline in vascular function remains unclear. We examined the function of the vascular prostanoid system in matched pre- and postmenopausal women before and after 12 weeks of exercise training. Twenty premenopausal and 16 early postmenopausal (3.1±0.5 [mean±SE] years after final menstrual period) women only separated by 4 (50±0 versus 54±1) years of age were included. Before the training period, the vasodilator response to intra-arterial infusion of either the prostacyclin analog epoprostenol or acetylcholine was lower (≈13%-41%; P<0.05) in the postmenopausal compared with the premenopausal women. Acetylcholine infusion induced a similar release of prostacyclin (6-keto prostaglandin F1a). To elucidate the role of vasoconstrictor prostanoids, acetylcholine infusion was combined with the cyclooxygenase inhibitor ketorolac and here the vascular response to acetylcholine was reduced to a similar extent in pre- and postmenopausal women. Exercise training increased (P<0.05) the vasodilator response to epoprostenol (≈100%-150%) and acetylcholine (≈100%-120%) infusion in the postmenopausal group. These findings demonstrate that the early postmenopausal phase is associated with a marked reduction in vascular function. Despite of a reduced sensitivity to prostacyclin, the overall balance between vasodilator and vasoconstrictor prostanoids does not seem to be altered. Exercise training can reverse the decline in vascular sensitivity to epoprostenol and acetylcholine, suggesting that beneficial vascular adaptations with exercise training are preserved in recent postmenopausal women.",
author = "Nyberg, {Michael Permin} and Jon Egelund and {Mandrup Jensen}, {Camilla Maria} and Nielsen, {Mads Bertram} and Mogensen, {Alexander Soare} and Stallknecht, {Bente Merete} and Jens Bangsbo and Ylva Hellsten",
note = "CURIS 2016 NEXS 237",
year = "2016",
doi = "10.1161/HYPERTENSIONAHA.116.07866",
language = "English",
volume = "68",
pages = "1011--1020",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams & Wilkins",
number = "4",

}

RIS

TY - JOUR

T1 - Early postmenopausal phase is associated with reduced prostacyclin-induced vasodilation that is reversed by exercise training

T2 - The Copenhagen Women Study

AU - Nyberg, Michael Permin

AU - Egelund, Jon

AU - Mandrup Jensen, Camilla Maria

AU - Nielsen, Mads Bertram

AU - Mogensen, Alexander Soare

AU - Stallknecht, Bente Merete

AU - Bangsbo, Jens

AU - Hellsten, Ylva

N1 - CURIS 2016 NEXS 237

PY - 2016

Y1 - 2016

N2 - The postmenopausal phase is associated with an accelerated rate of rise in the prevalence of vascular dysfunction and hypertension; however, the mechanisms underlying these adverse vascular changes and whether exercise training can reverse the decline in vascular function remains unclear. We examined the function of the vascular prostanoid system in matched pre- and postmenopausal women before and after 12 weeks of exercise training. Twenty premenopausal and 16 early postmenopausal (3.1±0.5 [mean±SE] years after final menstrual period) women only separated by 4 (50±0 versus 54±1) years of age were included. Before the training period, the vasodilator response to intra-arterial infusion of either the prostacyclin analog epoprostenol or acetylcholine was lower (≈13%-41%; P<0.05) in the postmenopausal compared with the premenopausal women. Acetylcholine infusion induced a similar release of prostacyclin (6-keto prostaglandin F1a). To elucidate the role of vasoconstrictor prostanoids, acetylcholine infusion was combined with the cyclooxygenase inhibitor ketorolac and here the vascular response to acetylcholine was reduced to a similar extent in pre- and postmenopausal women. Exercise training increased (P<0.05) the vasodilator response to epoprostenol (≈100%-150%) and acetylcholine (≈100%-120%) infusion in the postmenopausal group. These findings demonstrate that the early postmenopausal phase is associated with a marked reduction in vascular function. Despite of a reduced sensitivity to prostacyclin, the overall balance between vasodilator and vasoconstrictor prostanoids does not seem to be altered. Exercise training can reverse the decline in vascular sensitivity to epoprostenol and acetylcholine, suggesting that beneficial vascular adaptations with exercise training are preserved in recent postmenopausal women.

AB - The postmenopausal phase is associated with an accelerated rate of rise in the prevalence of vascular dysfunction and hypertension; however, the mechanisms underlying these adverse vascular changes and whether exercise training can reverse the decline in vascular function remains unclear. We examined the function of the vascular prostanoid system in matched pre- and postmenopausal women before and after 12 weeks of exercise training. Twenty premenopausal and 16 early postmenopausal (3.1±0.5 [mean±SE] years after final menstrual period) women only separated by 4 (50±0 versus 54±1) years of age were included. Before the training period, the vasodilator response to intra-arterial infusion of either the prostacyclin analog epoprostenol or acetylcholine was lower (≈13%-41%; P<0.05) in the postmenopausal compared with the premenopausal women. Acetylcholine infusion induced a similar release of prostacyclin (6-keto prostaglandin F1a). To elucidate the role of vasoconstrictor prostanoids, acetylcholine infusion was combined with the cyclooxygenase inhibitor ketorolac and here the vascular response to acetylcholine was reduced to a similar extent in pre- and postmenopausal women. Exercise training increased (P<0.05) the vasodilator response to epoprostenol (≈100%-150%) and acetylcholine (≈100%-120%) infusion in the postmenopausal group. These findings demonstrate that the early postmenopausal phase is associated with a marked reduction in vascular function. Despite of a reduced sensitivity to prostacyclin, the overall balance between vasodilator and vasoconstrictor prostanoids does not seem to be altered. Exercise training can reverse the decline in vascular sensitivity to epoprostenol and acetylcholine, suggesting that beneficial vascular adaptations with exercise training are preserved in recent postmenopausal women.

U2 - 10.1161/HYPERTENSIONAHA.116.07866

DO - 10.1161/HYPERTENSIONAHA.116.07866

M3 - Journal article

C2 - 27550922

VL - 68

SP - 1011

EP - 1020

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 4

ER -

ID: 164816311