Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass

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Standard

Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass. / Bojsen-Møller, Kirstine N; Dirksen, Carsten; Jørgensen, Nils Bruun; Jacobsen, Siv Hesse; Serup, Annette Karen Lundbeck; Albers, Peter Hjorth; Hansen, Dorte L; Worm, Dorte; Naver, Lars; Kristiansen, Viggo B; Wojtaszewski, Jørgen; Kiens, Bente; Holst, Jens Juul; Richter, Erik A.; Madsbad, Sten.

I: Diabetes, Bind 63, Nr. 5, 2014, s. 1725-1737.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Bojsen-Møller, KN, Dirksen, C, Jørgensen, NB, Jacobsen, SH, Serup, AKL, Albers, PH, Hansen, DL, Worm, D, Naver, L, Kristiansen, VB, Wojtaszewski, J, Kiens, B, Holst, JJ, Richter, EA & Madsbad, S 2014, 'Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass', Diabetes, bind 63, nr. 5, s. 1725-1737. https://doi.org/10.2337/db13-1307

APA

Bojsen-Møller, K. N., Dirksen, C., Jørgensen, N. B., Jacobsen, S. H., Serup, A. K. L., Albers, P. H., Hansen, D. L., Worm, D., Naver, L., Kristiansen, V. B., Wojtaszewski, J., Kiens, B., Holst, J. J., Richter, E. A., & Madsbad, S. (2014). Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass. Diabetes, 63(5), 1725-1737. https://doi.org/10.2337/db13-1307

Vancouver

Bojsen-Møller KN, Dirksen C, Jørgensen NB, Jacobsen SH, Serup AKL, Albers PH o.a. Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass. Diabetes. 2014;63(5):1725-1737. https://doi.org/10.2337/db13-1307

Author

Bojsen-Møller, Kirstine N ; Dirksen, Carsten ; Jørgensen, Nils Bruun ; Jacobsen, Siv Hesse ; Serup, Annette Karen Lundbeck ; Albers, Peter Hjorth ; Hansen, Dorte L ; Worm, Dorte ; Naver, Lars ; Kristiansen, Viggo B ; Wojtaszewski, Jørgen ; Kiens, Bente ; Holst, Jens Juul ; Richter, Erik A. ; Madsbad, Sten. / Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass. I: Diabetes. 2014 ; Bind 63, Nr. 5. s. 1725-1737.

Bibtex

@article{0da717e3af254724a63eb8ebcbec5281,
title = "Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass",
abstract = "Roux-en-Y gastric bypass (RYGB) improves glycemic control within days after surgery, and changes in insulin sensitivity and beta-cell function are likely to be involved. We studied 10 obese patients with type 2 diabetes and 10 obese glucose tolerant subjects before, 1 week, 3 months and 1 year after RYGB. Participants were included after a preoperative diet induced total weight loss of -9.2±1.2%. Hepatic and peripheral insulin sensitivity were assessed using the hyperinsulinemic euglycemic clamp combined with glucose tracer technique and beta-cell function evaluated in response to an intravenous glucose-glucagon challenge as well as an oral glucose load. Already within 1 week, RYGB reduced basal glucose production, improved basal hepatic insulin sensitivity and increased insulin clearance highlighting the liver as an important organ responsible for the early effects on glucose metabolism after surgery. Insulin mediated glucose disposal and suppression of fatty acids did not improve immediately after surgery but increased at 3 months and 1 year likely related to the reduction in body weight. Insulin secretion increased after RYGB, but only in patients with type 2 diabetes and only in response to oral glucose, underscoring the importance of the changed gut anatomy.",
author = "Bojsen-M{\o}ller, {Kirstine N} and Carsten Dirksen and J{\o}rgensen, {Nils Bruun} and Jacobsen, {Siv Hesse} and Serup, {Annette Karen Lundbeck} and Albers, {Peter Hjorth} and Hansen, {Dorte L} and Dorte Worm and Lars Naver and Kristiansen, {Viggo B} and J{\o}rgen Wojtaszewski and Bente Kiens and Holst, {Jens Juul} and Richter, {Erik A.} and Sten Madsbad",
note = "CURIS 2014 NEXS 121",
year = "2014",
doi = "10.2337/db13-1307",
language = "English",
volume = "63",
pages = "1725--1737",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "5",

}

RIS

TY - JOUR

T1 - Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass

AU - Bojsen-Møller, Kirstine N

AU - Dirksen, Carsten

AU - Jørgensen, Nils Bruun

AU - Jacobsen, Siv Hesse

AU - Serup, Annette Karen Lundbeck

AU - Albers, Peter Hjorth

AU - Hansen, Dorte L

AU - Worm, Dorte

AU - Naver, Lars

AU - Kristiansen, Viggo B

AU - Wojtaszewski, Jørgen

AU - Kiens, Bente

AU - Holst, Jens Juul

AU - Richter, Erik A.

AU - Madsbad, Sten

N1 - CURIS 2014 NEXS 121

PY - 2014

Y1 - 2014

N2 - Roux-en-Y gastric bypass (RYGB) improves glycemic control within days after surgery, and changes in insulin sensitivity and beta-cell function are likely to be involved. We studied 10 obese patients with type 2 diabetes and 10 obese glucose tolerant subjects before, 1 week, 3 months and 1 year after RYGB. Participants were included after a preoperative diet induced total weight loss of -9.2±1.2%. Hepatic and peripheral insulin sensitivity were assessed using the hyperinsulinemic euglycemic clamp combined with glucose tracer technique and beta-cell function evaluated in response to an intravenous glucose-glucagon challenge as well as an oral glucose load. Already within 1 week, RYGB reduced basal glucose production, improved basal hepatic insulin sensitivity and increased insulin clearance highlighting the liver as an important organ responsible for the early effects on glucose metabolism after surgery. Insulin mediated glucose disposal and suppression of fatty acids did not improve immediately after surgery but increased at 3 months and 1 year likely related to the reduction in body weight. Insulin secretion increased after RYGB, but only in patients with type 2 diabetes and only in response to oral glucose, underscoring the importance of the changed gut anatomy.

AB - Roux-en-Y gastric bypass (RYGB) improves glycemic control within days after surgery, and changes in insulin sensitivity and beta-cell function are likely to be involved. We studied 10 obese patients with type 2 diabetes and 10 obese glucose tolerant subjects before, 1 week, 3 months and 1 year after RYGB. Participants were included after a preoperative diet induced total weight loss of -9.2±1.2%. Hepatic and peripheral insulin sensitivity were assessed using the hyperinsulinemic euglycemic clamp combined with glucose tracer technique and beta-cell function evaluated in response to an intravenous glucose-glucagon challenge as well as an oral glucose load. Already within 1 week, RYGB reduced basal glucose production, improved basal hepatic insulin sensitivity and increased insulin clearance highlighting the liver as an important organ responsible for the early effects on glucose metabolism after surgery. Insulin mediated glucose disposal and suppression of fatty acids did not improve immediately after surgery but increased at 3 months and 1 year likely related to the reduction in body weight. Insulin secretion increased after RYGB, but only in patients with type 2 diabetes and only in response to oral glucose, underscoring the importance of the changed gut anatomy.

U2 - 10.2337/db13-1307

DO - 10.2337/db13-1307

M3 - Journal article

C2 - 24241533

VL - 63

SP - 1725

EP - 1737

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 5

ER -

ID: 81633202