Contraction-associated translocation of protein kinase C in rat skeletal muscle

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Electrical stimulation of the sciatic nerve of the anaesthetized rat in vivo led to a time-dependent translocation of protein kinase C from the muscle cytosol to the particulate fraction. Maximum activity of protein kinase C in the particulate fraction occurred after 2 min of intermittent short tetanic contractions of the gastrocnemius-plantaris-soleus muscle group and coincided with the loss of activity from the cytosol. Translocation of protein kinase C may imply a role for this kinase in contraction-initiated changes in muscle metabolism.

OriginalsprogEngelsk
TidsskriftFEBS letters
Vol/bind217
Udgave nummer2
Sider (fra-til)232-236
Antal sider5
ISSN0014-5793
StatusUdgivet - 1987

ID: 154757954