Causes of vitamin K deficiency in patients on haemodialysis

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Causes of vitamin K deficiency in patients on haemodialysis. / Wikstrøm, Signe; Aagaard Lentz, Katrine; Hansen, Ditte; Melholt Rasmussen, Lars; Jakobsen, Jette; Post Hansen, Henrik; Andersen, Jens Rikardt.

I: Nutrients, Bind 12, Nr. 9, 2513, 2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Wikstrøm, S, Aagaard Lentz, K, Hansen, D, Melholt Rasmussen, L, Jakobsen, J, Post Hansen, H & Andersen, JR 2020, 'Causes of vitamin K deficiency in patients on haemodialysis', Nutrients, bind 12, nr. 9, 2513. https://doi.org/10.3390/nu12092513

APA

Wikstrøm, S., Aagaard Lentz, K., Hansen, D., Melholt Rasmussen, L., Jakobsen, J., Post Hansen, H., & Andersen, J. R. (2020). Causes of vitamin K deficiency in patients on haemodialysis. Nutrients, 12(9), [2513]. https://doi.org/10.3390/nu12092513

Vancouver

Wikstrøm S, Aagaard Lentz K, Hansen D, Melholt Rasmussen L, Jakobsen J, Post Hansen H o.a. Causes of vitamin K deficiency in patients on haemodialysis. Nutrients. 2020;12(9). 2513. https://doi.org/10.3390/nu12092513

Author

Wikstrøm, Signe ; Aagaard Lentz, Katrine ; Hansen, Ditte ; Melholt Rasmussen, Lars ; Jakobsen, Jette ; Post Hansen, Henrik ; Andersen, Jens Rikardt. / Causes of vitamin K deficiency in patients on haemodialysis. I: Nutrients. 2020 ; Bind 12, Nr. 9.

Bibtex

@article{9761b632e84f487881a8b1498a7439b5,
title = "Causes of vitamin K deficiency in patients on haemodialysis",
abstract = "Background: A low vitamin K status is common in patients on haemodialysis, and this is considered one of the reasons for the accelerated atherosclerosis in these patients. The vitamin is essential in activation of the protein Matrix Gla Protein (MGP), and the inactive form, dp-ucMGP, is used to measure vitamin K status. The purpose of this study was to investigate possible underlying causes of low vitamin K status, which could potentially be low intake, washout during dialysis or inhibited absorption capacity. Moreover, the aim was to investigate whether the biomarker dp-ucMGP is affected in these patients. Method: Vitamin K intake was assessed by a Food Frequency Questionnaire (FFQ) and absorption capacity by means of D-xylose testing. dp-ucMGP was measured in plasma before and after dialysis, and phylloquinine (vitamin K1) and dp-ucMGP were measured in the dialysate. Changes in dp-ucMGP were measured after 14 days of protein supplementation. Results: All patients had plasma dp-ucMGP above 750 pmol/L, and a low intake of vitamin K. The absorption capacity was normal. The difference in dp-ucMGP before and after dialysis was -1022 pmol/L (p < 0.001). Vitamin K1 was not present in the dialysate but dp-ucMGP was at a high concentration. The change in dp-ucMGP before and after protein supplementation was -165 pmol/L (p = 0.06). Conclusion: All patients had vitamin K deficiency. The reason for the low vitamin K status is not due to removal of vitamin K during dialysis or decreased absorption but is plausibly due to a low intake of vitamin K in food. dp-ucMGP is washed out during dialysis, but not affected by protein intake to a clinically relevant degree.",
keywords = "Faculty of Science, Haemodialysis, Vitamin K, Phylloquinone, Menaquinone, dp-ucMGP, D-xylose test",
author = "Signe Wikstr{\o}m and {Aagaard Lentz}, Katrine and Ditte Hansen and {Melholt Rasmussen}, Lars and Jette Jakobsen and {Post Hansen}, Henrik and Andersen, {Jens Rikardt}",
note = "CURIS 2020 NEXS 283",
year = "2020",
doi = "10.3390/nu12092513",
language = "English",
volume = "12",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "9",

}

RIS

TY - JOUR

T1 - Causes of vitamin K deficiency in patients on haemodialysis

AU - Wikstrøm, Signe

AU - Aagaard Lentz, Katrine

AU - Hansen, Ditte

AU - Melholt Rasmussen, Lars

AU - Jakobsen, Jette

AU - Post Hansen, Henrik

AU - Andersen, Jens Rikardt

N1 - CURIS 2020 NEXS 283

PY - 2020

Y1 - 2020

N2 - Background: A low vitamin K status is common in patients on haemodialysis, and this is considered one of the reasons for the accelerated atherosclerosis in these patients. The vitamin is essential in activation of the protein Matrix Gla Protein (MGP), and the inactive form, dp-ucMGP, is used to measure vitamin K status. The purpose of this study was to investigate possible underlying causes of low vitamin K status, which could potentially be low intake, washout during dialysis or inhibited absorption capacity. Moreover, the aim was to investigate whether the biomarker dp-ucMGP is affected in these patients. Method: Vitamin K intake was assessed by a Food Frequency Questionnaire (FFQ) and absorption capacity by means of D-xylose testing. dp-ucMGP was measured in plasma before and after dialysis, and phylloquinine (vitamin K1) and dp-ucMGP were measured in the dialysate. Changes in dp-ucMGP were measured after 14 days of protein supplementation. Results: All patients had plasma dp-ucMGP above 750 pmol/L, and a low intake of vitamin K. The absorption capacity was normal. The difference in dp-ucMGP before and after dialysis was -1022 pmol/L (p < 0.001). Vitamin K1 was not present in the dialysate but dp-ucMGP was at a high concentration. The change in dp-ucMGP before and after protein supplementation was -165 pmol/L (p = 0.06). Conclusion: All patients had vitamin K deficiency. The reason for the low vitamin K status is not due to removal of vitamin K during dialysis or decreased absorption but is plausibly due to a low intake of vitamin K in food. dp-ucMGP is washed out during dialysis, but not affected by protein intake to a clinically relevant degree.

AB - Background: A low vitamin K status is common in patients on haemodialysis, and this is considered one of the reasons for the accelerated atherosclerosis in these patients. The vitamin is essential in activation of the protein Matrix Gla Protein (MGP), and the inactive form, dp-ucMGP, is used to measure vitamin K status. The purpose of this study was to investigate possible underlying causes of low vitamin K status, which could potentially be low intake, washout during dialysis or inhibited absorption capacity. Moreover, the aim was to investigate whether the biomarker dp-ucMGP is affected in these patients. Method: Vitamin K intake was assessed by a Food Frequency Questionnaire (FFQ) and absorption capacity by means of D-xylose testing. dp-ucMGP was measured in plasma before and after dialysis, and phylloquinine (vitamin K1) and dp-ucMGP were measured in the dialysate. Changes in dp-ucMGP were measured after 14 days of protein supplementation. Results: All patients had plasma dp-ucMGP above 750 pmol/L, and a low intake of vitamin K. The absorption capacity was normal. The difference in dp-ucMGP before and after dialysis was -1022 pmol/L (p < 0.001). Vitamin K1 was not present in the dialysate but dp-ucMGP was at a high concentration. The change in dp-ucMGP before and after protein supplementation was -165 pmol/L (p = 0.06). Conclusion: All patients had vitamin K deficiency. The reason for the low vitamin K status is not due to removal of vitamin K during dialysis or decreased absorption but is plausibly due to a low intake of vitamin K in food. dp-ucMGP is washed out during dialysis, but not affected by protein intake to a clinically relevant degree.

KW - Faculty of Science

KW - Haemodialysis

KW - Vitamin K

KW - Phylloquinone

KW - Menaquinone

KW - dp-ucMGP

KW - D-xylose test

U2 - 10.3390/nu12092513

DO - 10.3390/nu12092513

M3 - Journal article

C2 - 32825243

VL - 12

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 9

M1 - 2513

ER -

ID: 247876075