β2-Adrenergic agonist salbutamol augments hypertrophy in MHCIIa fibers and sprint mean power output but not muscle force during 11 weeks of resistance training in young men

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

β2-Adrenergic agonist salbutamol augments hypertrophy in MHCIIa fibers and sprint mean power output but not muscle force during 11 weeks of resistance training in young men. / Jessen, Søren; Reitelseder, Søren; Kalsen, Anders; Kreiberg, Michael; Onslev, Johan; Gad, Anders; Ørtenblad, Niels; Backer, Vibeke; Holm, Lars; Bangsbo, Jens; Hostrup, Morten.

I: Journal of Applied Physiology, Bind 130, Nr. 3, 2021, s. 617-626.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Jessen, S, Reitelseder, S, Kalsen, A, Kreiberg, M, Onslev, J, Gad, A, Ørtenblad, N, Backer, V, Holm, L, Bangsbo, J & Hostrup, M 2021, 'β2-Adrenergic agonist salbutamol augments hypertrophy in MHCIIa fibers and sprint mean power output but not muscle force during 11 weeks of resistance training in young men', Journal of Applied Physiology, bind 130, nr. 3, s. 617-626. https://doi.org/10.1152/japplphysiol.00553.2020

APA

Jessen, S., Reitelseder, S., Kalsen, A., Kreiberg, M., Onslev, J., Gad, A., Ørtenblad, N., Backer, V., Holm, L., Bangsbo, J., & Hostrup, M. (2021). β2-Adrenergic agonist salbutamol augments hypertrophy in MHCIIa fibers and sprint mean power output but not muscle force during 11 weeks of resistance training in young men. Journal of Applied Physiology, 130(3), 617-626. https://doi.org/10.1152/japplphysiol.00553.2020

Vancouver

Jessen S, Reitelseder S, Kalsen A, Kreiberg M, Onslev J, Gad A o.a. β2-Adrenergic agonist salbutamol augments hypertrophy in MHCIIa fibers and sprint mean power output but not muscle force during 11 weeks of resistance training in young men. Journal of Applied Physiology. 2021;130(3):617-626. https://doi.org/10.1152/japplphysiol.00553.2020

Author

Jessen, Søren ; Reitelseder, Søren ; Kalsen, Anders ; Kreiberg, Michael ; Onslev, Johan ; Gad, Anders ; Ørtenblad, Niels ; Backer, Vibeke ; Holm, Lars ; Bangsbo, Jens ; Hostrup, Morten. / β2-Adrenergic agonist salbutamol augments hypertrophy in MHCIIa fibers and sprint mean power output but not muscle force during 11 weeks of resistance training in young men. I: Journal of Applied Physiology. 2021 ; Bind 130, Nr. 3. s. 617-626.

Bibtex

@article{cad0a62638bb4d0594ca3ddbe96c4570,
title = "β2-Adrenergic agonist salbutamol augments hypertrophy in MHCIIa fibers and sprint mean power output but not muscle force during 11 weeks of resistance training in young men",
abstract = "In this study, we examined the effect of β2-agonist salbutamol at oral doses during a period of resistance training on sprint performance, quadriceps contractile function, skeletal muscle hypertrophy, fiber type composition, maximal activity of enzymes of importance for anaerobic energy turnover, and sarcoplasmic reticulum Ca2+ handling in young men. Twenty-six men (23 ± 2 yr; means ± SD) were randomized to daily intake of oral salbutamol (16 mg/day; RES+SAL) or placebo (RES) during 11 wk of full-body resistance training 3 times/wk. Mean power output during 10-s maximal cycling increased more (P = 0.027) in RES+SAL (+ 12%) than in RES ( {\th} 7%), whereas peak power output increased similarly (RES+SAL: + 8%; RES: + 7%; P = 0.400). Quadriceps dynamic peak torque and maximal voluntary isometric torque increased by 13 and 14% (P ≤ 0.001) in RES+SAL and 13 and 13% (P ≤ 0.001) in RES, respectively. Myosin heavy-chain (MHC) isoform distribution transitioned from MHCI and MHCIIx toward MHCIIa in RES+SAL (P = 0.002), but not in RES (P = 0.323). MHCIIa cross-sectional-area increased more (P = 0.040) in RES+SAL (+ 35%) than RES (+ 21%). Sarcoplasmic reticulum Ca2+ release rate increased in both groups (RES+SAL: + 9%, P = 0.048; RES: + 13%, P = 0.008), whereas Ca2+-uptake rate increased only in RES (+ 12%, P = 0.022) but was not different from the non-significant change in RES+SAL (+ 2%, P = 0.484). Maximal activity of lactate dehydrogenase increased only in RES+SAL (+ 13%, P = 0.008). Muscle content of the dihydropyridine receptor, ryanodine receptor 1, and sarcoplasmic reticulum Ca2+-ATPase iso-form 1 and 2 did not change with the intervention in either group (P ≥ 0.100). These observations indicate that the enhancement of sprint mean power output induced by salbutamol is at least partly attributed to greater hypertrophy of MHCIIa fibers and transition toward the MHCIIa isoform.",
keywords = "Faculty of Science, Adrenoceptors, Athletes, Kin-com, Dynamometer, Doping",
author = "S{\o}ren Jessen and S{\o}ren Reitelseder and Anders Kalsen and Michael Kreiberg and Johan Onslev and Anders Gad and Niels {\O}rtenblad and Vibeke Backer and Lars Holm and Jens Bangsbo and Morten Hostrup",
note = "CURIS 2021 NEXS 099",
year = "2021",
doi = "10.1152/japplphysiol.00553.2020",
language = "English",
volume = "130",
pages = "617--626",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "3",

}

RIS

TY - JOUR

T1 - β2-Adrenergic agonist salbutamol augments hypertrophy in MHCIIa fibers and sprint mean power output but not muscle force during 11 weeks of resistance training in young men

AU - Jessen, Søren

AU - Reitelseder, Søren

AU - Kalsen, Anders

AU - Kreiberg, Michael

AU - Onslev, Johan

AU - Gad, Anders

AU - Ørtenblad, Niels

AU - Backer, Vibeke

AU - Holm, Lars

AU - Bangsbo, Jens

AU - Hostrup, Morten

N1 - CURIS 2021 NEXS 099

PY - 2021

Y1 - 2021

N2 - In this study, we examined the effect of β2-agonist salbutamol at oral doses during a period of resistance training on sprint performance, quadriceps contractile function, skeletal muscle hypertrophy, fiber type composition, maximal activity of enzymes of importance for anaerobic energy turnover, and sarcoplasmic reticulum Ca2+ handling in young men. Twenty-six men (23 ± 2 yr; means ± SD) were randomized to daily intake of oral salbutamol (16 mg/day; RES+SAL) or placebo (RES) during 11 wk of full-body resistance training 3 times/wk. Mean power output during 10-s maximal cycling increased more (P = 0.027) in RES+SAL (+ 12%) than in RES ( þ 7%), whereas peak power output increased similarly (RES+SAL: + 8%; RES: + 7%; P = 0.400). Quadriceps dynamic peak torque and maximal voluntary isometric torque increased by 13 and 14% (P ≤ 0.001) in RES+SAL and 13 and 13% (P ≤ 0.001) in RES, respectively. Myosin heavy-chain (MHC) isoform distribution transitioned from MHCI and MHCIIx toward MHCIIa in RES+SAL (P = 0.002), but not in RES (P = 0.323). MHCIIa cross-sectional-area increased more (P = 0.040) in RES+SAL (+ 35%) than RES (+ 21%). Sarcoplasmic reticulum Ca2+ release rate increased in both groups (RES+SAL: + 9%, P = 0.048; RES: + 13%, P = 0.008), whereas Ca2+-uptake rate increased only in RES (+ 12%, P = 0.022) but was not different from the non-significant change in RES+SAL (+ 2%, P = 0.484). Maximal activity of lactate dehydrogenase increased only in RES+SAL (+ 13%, P = 0.008). Muscle content of the dihydropyridine receptor, ryanodine receptor 1, and sarcoplasmic reticulum Ca2+-ATPase iso-form 1 and 2 did not change with the intervention in either group (P ≥ 0.100). These observations indicate that the enhancement of sprint mean power output induced by salbutamol is at least partly attributed to greater hypertrophy of MHCIIa fibers and transition toward the MHCIIa isoform.

AB - In this study, we examined the effect of β2-agonist salbutamol at oral doses during a period of resistance training on sprint performance, quadriceps contractile function, skeletal muscle hypertrophy, fiber type composition, maximal activity of enzymes of importance for anaerobic energy turnover, and sarcoplasmic reticulum Ca2+ handling in young men. Twenty-six men (23 ± 2 yr; means ± SD) were randomized to daily intake of oral salbutamol (16 mg/day; RES+SAL) or placebo (RES) during 11 wk of full-body resistance training 3 times/wk. Mean power output during 10-s maximal cycling increased more (P = 0.027) in RES+SAL (+ 12%) than in RES ( þ 7%), whereas peak power output increased similarly (RES+SAL: + 8%; RES: + 7%; P = 0.400). Quadriceps dynamic peak torque and maximal voluntary isometric torque increased by 13 and 14% (P ≤ 0.001) in RES+SAL and 13 and 13% (P ≤ 0.001) in RES, respectively. Myosin heavy-chain (MHC) isoform distribution transitioned from MHCI and MHCIIx toward MHCIIa in RES+SAL (P = 0.002), but not in RES (P = 0.323). MHCIIa cross-sectional-area increased more (P = 0.040) in RES+SAL (+ 35%) than RES (+ 21%). Sarcoplasmic reticulum Ca2+ release rate increased in both groups (RES+SAL: + 9%, P = 0.048; RES: + 13%, P = 0.008), whereas Ca2+-uptake rate increased only in RES (+ 12%, P = 0.022) but was not different from the non-significant change in RES+SAL (+ 2%, P = 0.484). Maximal activity of lactate dehydrogenase increased only in RES+SAL (+ 13%, P = 0.008). Muscle content of the dihydropyridine receptor, ryanodine receptor 1, and sarcoplasmic reticulum Ca2+-ATPase iso-form 1 and 2 did not change with the intervention in either group (P ≥ 0.100). These observations indicate that the enhancement of sprint mean power output induced by salbutamol is at least partly attributed to greater hypertrophy of MHCIIa fibers and transition toward the MHCIIa isoform.

KW - Faculty of Science

KW - Adrenoceptors

KW - Athletes

KW - Kin-com

KW - Dynamometer

KW - Doping

U2 - 10.1152/japplphysiol.00553.2020

DO - 10.1152/japplphysiol.00553.2020

M3 - Journal article

C2 - 33357007

VL - 130

SP - 617

EP - 626

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 3

ER -

ID: 254471547