A PGC-1α- and muscle fibre type-related decrease in markers of mitochondrial oxidative metabolism in skeletal muscle of humans with inherited insulin resistance

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Jonas Møller Kristensen, Vibe Skov, Stine Juhl Petersson, Niels Ørtenblad, Jørgen Wojtaszewski, Henning Beck-Nielsen, Kurt Højlund

Insulin resistance in obesity and type 2 diabetes is related to abnormalities in mitochondrial oxidative phosphorylation (OxPhos) in skeletal muscle. We tested the hypothesis that mitochondrial oxidative metabolism is impaired in muscle of patients with inherited insulin resistance and defective insulin signalling.
OriginalsprogEngelsk
TidsskriftDiabetologia
Vol/bind57
Udgave nummer5
Sider (fra-til)1006-1015
Antal sider10
ISSN0012-186X
DOI
StatusUdgivet - 2014

Bibliografisk note

CURIS 2014 NEXS 049

ID: 99123126