5'-AMP activated protein kinase is involved in the regulation of myocardial ß-oxidative capacity in mice

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

5'-adenosine monophosphate-activated protein kinase (AMPK) is considered central in regulation of energy status and substrate utilization within cells. In heart failure the energetic state is compromised and substrate metabolism is altered. We hypothesized that this could be linked to changes in AMPK activity and we therefore investigated mitochondrial oxidative phosphorylation capacity from the oxidation of long- and medium-chain fatty acids (LCFA and MCFA) in cardiomyocytes from young and old mice expressing a dominant negative AMPKa2 (AMPKa2-KD) construct and their wildtype (WT) littermates. We found a 35-45% (P¿
TidsskriftFrontiers in Physiology
Antal sider7
StatusUdgivet - 22 feb. 2012

Bibliografisk note

CURIS 2012 5200 070

ID: 38566098